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Biocompatible Surface Coatings for Silicone-Based Implants
Published in Gilson Khang, Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2017
Jiyeon Ham, Sunah Kang, Ji-Ung Park, Yan Leea
With the growing interest in beauty and antiaging, demands for plastic surgery are rapidly increasing worldwide. Breast augmentation is one of the most representative forms of plastic surgery accounting for 15% of all cosmetic surgical procedures.1 Moreover, breast reconstruction is becoming increasingly important for patients who have had mastectomies to remove cancerous breast tissues.2 In most cases, silicone-based bags filled with saline or silicone cohesive gel are used as the breast implants.3 Both the silicone bags and the cohesive filling gels are made of poly(dimethylsiloxane) (PDMS) with different crosslinking degrees (Fig. 40.1). PDMS has been used as the implantable materials due to its inert, malleable, and deformable characteristics. Although the breast tissue–like mechanical properties and the moderate price of the silicone implants generally satisfy the patients, infection during the surgical procedure and the limited biocompatibility of the silicone surface often induce dissatisfaction with severe side effects. Approximately 4.3%–20% of patients receive surgical intervention because of capsular contracture, hematoma/seroma, infection, asymmetry with displacement, rippling of skin, pain, and rupture. Among them, the most prominent complication is capsular contracture, which accounts for 16.2%–55% of all cases of revision surgery.4,5–6
Medical textiles
Published in Textile Progress, 2020
In plastic surgery, the most common wound complications are tissue reactivity, infections and wound dehiscence. It is well known that choice of suture material is imperative to appropriate wound closure. The ‘perfect’ suture material should be of uniform calibre (possess uniform linear density), be readily available, be reasonably inexpensive and easy to sterilize, elastic, supple and have good tensile strength. In one study of 1000 plastic surgical wounds [322], the wounds were evaluated at days 3, 7 and 14 post operation for three outcomes of interest: tissue reactivity, wound dehiscence and local infection. Monofilament non-absorbable sutures used in the study included nylon. Multifilament absorbable sutures of catgut, polglycolic acid and polyglactin (a copolymer of glycolic and lactic acid) were used. Multifilament non-absorbable synthetic sutures of braided polyamide and polyester and natural sutures of silk were used.