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Chapter 2: Application of Microspheres to Measure Cell Surface- Associated Proteolytic Enzyme Activities
Published in Alan Rembaum, Zoltán A. Tökés, Micro spheres: Medical and Biological Applications, 2017
Human breast and prostate adenocarcinoma cells— The human breast adenocarcinoma cell line MCF-7, passages 6 to 14 and 78 to 88, and HBL-100 were obtained from Dr. David Kingsbury at Naval Biosciences Laboratory, Oakland, and from the Mason Research Institute, Worcester, Mass. Prostate carcinoma cell line PC-3 was established from a poorly differentiated human prostate adenocarcinoma which had metastasized to bone.14
Methanolic extract of Teucrium persicum up-regulates and induces the membrane restoration of E-cadherin protein in PC-3 cells
Published in International Journal of Environmental Health Research, 2023
Majid Tafrihi, Anahita Naeimi, Fatemeh Eizadifard
PC-3 cells are highly invasive and metastatic with a mesenchymal phenotype that is appropriate for anticancer agents (Tai et al. 2011). Our previous study showed that the treatment of PC-3 cells with methanolic extract of T. persicum leads to membrane localization of β-catenin protein and induction of epithelial-like morphology (Barati et al. 2021). Regarding the β-catenin as a partner of E-cadherin protein in adherence junctions (Zhu et al. 2020), we decided to evaluate the effect of T. persicum methanolic extract on the expression and cellular localization of E-cadherin protein in PC-3 cells.
Impacts of the prostate stem cell antigen (PSCA) and Clostridium perfringens enterotoxin (CPE) on the apoptosis and cell cycle regulatory genes in PC3
Published in Preparative Biochemistry & Biotechnology, 2020
Saied Abedi, Abbas Doosti, Mohammad-Saied Jami
There are some PCa cell lines that are used for research purposes. PC3 with a doubling time of approximately 33 h[21] is a cell line isolated from a vertebral metastatic prostate tumor in 1979.[22] It is also hormone insensitive and presents no androgen receptors (AR) or PSA mRNA/protein. It was first described as a human prostatic adenocarcinoma metastatic cell which has a greatly reduced dependence upon serum for growth.[23]
Characterization of the in vitro cytotoxic effects of brachydins isolated from Fridericia platyphylla in a prostate cancer cell line
Published in Journal of Toxicology and Environmental Health, Part A, 2020
Higor Lopes Nunes, Katiuska Tuttis, Juliana Mara Serpeloni, Jessyane Rodrigues do Nascimento, Claudia Quintino da Rocha, Viviane Aline Oliveira Silva, André van Helvoort Lengert, Rui Manuel Reis, Ilce Mara de Syllos Cólus
The three classical prostate cancer cell lines, namely, DU145, PC-3, and LNCaP, are most widely used in prostate cancer research (Namekawa et al. 2019). Further, the PC-3 cell line was used in the present study as an in vitro model to assess the effects of brachydins.