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Sustainable Green Polymeric Nanoconstructs for Active and Passive Cancer Therapeutics
Published in Vladimir Torchilin, Handbook of Materials for Nanomedicine, 2020
Ankit Rochani, Sreejith Raveendran, D. Sakthi Kumar
Being an FDA-approved polymer, HES was used for the development of 160 ± 5 nm size NPs for the delivery of the anticancer drug. The study showed that the formulation was found to be hemo-and cytocompatible under both in vivo and in vitro conditions and can be used for the anticancer therapy [99]. HES has also been used for developing strategy of the dual mode of cancer cell destruction attributed to chemotherapeutic (drug like cisplatin) and magnetic hyperthermia effects [100]. Later, HES-grafted PLA (HES-g-PLA) polymer was developed for the synthesis of DOX-loaded HES-g-PLA NPs with an average particle size of 130 nm as shown in Fig. 7.5 [97]. Similarly, carboxyl derivative of HES (carboxy-HES) was also synthesized for the nanodrug delivery of DOX. These particles were proposed to be formed by ionic interaction between the amino group of DOX and carboxyl group of carboxy-HES [101]. The study showed that the formulation works well under in vitro condition against DU145 prostate cancer cell line.
Characterization of the in vitro cytotoxic effects of brachydins isolated from Fridericia platyphylla in a prostate cancer cell line
Published in Journal of Toxicology and Environmental Health, Part A, 2020
Higor Lopes Nunes, Katiuska Tuttis, Juliana Mara Serpeloni, Jessyane Rodrigues do Nascimento, Claudia Quintino da Rocha, Viviane Aline Oliveira Silva, André van Helvoort Lengert, Rui Manuel Reis, Ilce Mara de Syllos Cólus
The three classical prostate cancer cell lines, namely, DU145, PC-3, and LNCaP, are most widely used in prostate cancer research (Namekawa et al. 2019). Further, the PC-3 cell line was used in the present study as an in vitro model to assess the effects of brachydins.
Two new Cu(II)-based coordination polymers: inhibitory activity on prostate cancer by reducing EGF-R expression and HIPPO signaling pathway activation
Published in Journal of Biomaterials Science, Polymer Edition, 2020
Xiang-Ying Wang, Jian Xiao, Hui-Qing Ma
In a word, in the conditions of solvothermal, two novel coordination polymers have been synthesized successfully. The analysis of single crystal X-ray diffraction has been utilized to measure their structures and the analysis of thermogravimetric (TG), powder X-ray diffraction (PXRD), the analysis of element as well as IR spectra have been further utilized to characterize the structures. The analyses of structure indicate that a three-dimensional 3,5-connected {4.62}2{42.69.84} net appears in complex 1. Although 2 shows a one-dimensional polymeric chains, via hydrogen bonding interactions, the polymeric chains were deep filled into three-dimensional supramolecular architectures. In biological research, their biological activity on the DU145 human prostate cancer cells was evaluated and the importance of the EGF-R as well as the HIPPO signaling pathway in the human prostate cancer cells was detected. The CCK-8 experiment was performed and the results showed that compound 1 exhibited stronger inhibitory effect on the viability of human prostate cancer cell compared with compound 2. In addition to this, compound 1 also showed much more excellent inhibitory activity than compound 2 on human prostate cancer cell migration and invasion ability. Besides, the western blotting results also suggested that there was a significantly increased expression of the EGF receptors on the human prostate cancer cells, which could be reversed by the compound treatment. Based on the previous results, we guess that the difference between compounds 1 and 2 was due to the different ligand in these two compounds, which made compound 1 enter the cancer cells more easily. In conclusion, compared with compound 2, compound 1 showed stronger inhibitory activity on the EGF-R relative expression and the activation level of the HIPPO signaling pathway in the human prostate cancer cells, which finally inhibit the proliferation of the cancer cells. In conclusion, the compound 1 has stronger inhibitory effect on the DU145 human prostate cancer cells by reduced the EGF receptors expression on the human prostate cancer cells, as well as the hippo and yap expression levels.