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The Emergence of Nanomedicine: A Vast Industry
Published in Paula V. Messina, Luciano A. Benedini, Damián Placente, Tomorrow’s Healthcare by Nano-sized Approaches, 2020
Paula V. Messina, Luciano A. Benedini, Damián Placente
Nanomedicine application to functional tissue restoration also reaches neurodegenerative disorders. Neuropathology processes that contribute to central nervous system ischemia, trauma, and degenerative conditions can be limited and even reversed by promoting neural regeneration and achieving neuroprotection. Nanotechnology approaches applied to neurodegenerative disorders should facilitate: (i) a rapid detection using nanotechnology tools, in particular, those that focus on chemically functionalized semiconductor quantum dots; (ii) neuroprotection by the delivery of drugs and small molecules across the blood–brain barrier for directly interacting, recording, and/or stimulating neurons at a molecular level, or limiting the damaging effects of free radicals generated after injury (iii) the functional regeneration of the nervous system by the development of nano-engineered scaffolds that support and promote neurite and axonal growth.
Nanostructured Drug Delivery of Nutraceuticals for Counteracting Oxidative Stress
Published in Bhupinder Singh, Minna Hakkarainen, Kamalinder K. Singh, NanoNutraceuticals, 2019
Shobhit Kumar, Bharti Gaba, Jasjeet K. Narang, Javed Ali, Sanjula Baboota
CoQ10 is a well-known endogenous antioxidant and also has anti-amyloidogenic activity. Both of these properties help in the treatment of disorders such as diabetes mellitus, CNS pathologies, and cancer. Generally, it is involved in energy production where it acts as a cofactor. It has the potential to block apoptosis mechanism of cell death and could be useful in the management and prevention of neuroprotective disorders (Young et al., 2007; Belhaj et al., 2012). Furthermore, it was investigated that it also delayed the amyloid beta-protein toxic effects, which makes its role useful in the prevention of Alzheimer’s disease (Young et al., 2007). In spite of its usefulness, poor oral bioavailability is a problem in clinical development of CoQ10, which is mainly caused by its poor aqueous solubility (<0.25 μg/mL). There is need to prepare carriers capable of improving CoQ10 solubility and stability. Different strategies have been applied for increasing CoQ10 solubility, such as liposomes, SNEDDS, and NLCs.
Efficacy and safety of mechanical thrombectomy in acute stroke patients with pre-morbid disability
Published in Expert Review of Medical Devices, 2022
Aravind Ganesh, Joachim Fladt, Nishita Singh, Mayank Goyal
As for patients with more significant disability (mRS≥3), we recommend pursuing a case-by-case approach to the use of acute stroke therapies, using shared decision-making with patients and/or their family members (Figure 1). In such discussions, it is important to acknowledge the spectrum of good and bad outcomes that may be achieved in these patients, disclosing the uncertain state of the evidence, and adopting patient-centered care strategies whenever possible. This includes taking into account each patient’s long-term goals of care. In addition, thrombectomy techniques and skills have improved drastically over the last few years, ensuring higher rates of successful reperfusion and better safety. Add-on therapies for neuroprotection-like nerenitide have shown promising results in preliminary large trials and are being studied further. Thus, overall acute care in stroke continues to improve which will in turn lead to better stroke outcomes and care in all patients presenting with stroke including those with preexisting disability.