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Principles and Biological Pathways to Tissue Regeneration: The Tissue Regenerative Niche
Published in Claudio Migliaresi, Antonella Motta, Scaffolds for Tissue Engineering, 2014
Ranieri Cancedda, Claudia Lo Sicco
Perivascular cells, often know as vascular mural cells, are the cells that surround tunica intima of the blood vessels that constitute a major component of the vascular wall. Pericytes, though similar but distinct from vascular smooth muscle cells, closely encircle capillaries and micro-vessels in most connective tissues. Pericytes have been postulated as the in situ counterpart of the bone marrow-derived MSCs [Sacchetti et al., 2007]. The CD146+CD105+ pericytes developed around the walls of capillaries regarded as structural elements of blood vessels that regulate vascular contractility and are important for the stabilization of the nascent capillaries and in the
Review on the current treatment status of vein of Galen malformations and future directions in research and treatment
Published in Expert Review of Medical Devices, 2021
Panagiotis Primikiris, Georgios Hadjigeorgiou, Maria Tsamopoulou, Alessandra Biondi, Christina Iosif
Different vessels (arteries, veins, and lymphatics) have different ranges of fluid shear stress [165,166], outside of which remodeling begins with an inflammatory activation of endothelium and recruitment of leukocytes [167,168]. Normal flow is approximately between 1 and 5 pascals (Pa) and highly pulsatile in arteries, it is of similar magnitude but less pulsatile in capillaries and about 10-fold less, with minimal pulsatility, in veins [164,169]. Flow within the normal range inhibits proliferation [170] and promotes recruitment of mural cells [171] stabilizing blood vessels. On the other hand, AVMs present with increased endothelial cell proliferation and impaired recruitment of perivascular cells [172].