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Hybrid x-ray luminescence and optical imaging
Published in Yi-Hwa Liu, Albert J. Sinusas, Hybrid Imaging in Cardiovascular Medicine, 2017
Raiyan T. Zaman, Michael V. McConnell, Lei Xing
Metals and other trace elements play an important role in many physiological processes in all biological systems. Characterization of precise metal concentrations, their spatial distribution, and chemical speciation in individual cells and cell compartments will provide much needed information to explore the metallome in health and disease. Ralle et al. described in their review article synchrotron-based x-ray fluorescent microscopy (SXRF) to be the ideal tool to quantitatively measure trace elements with high sensitivity at high resolution (Ralle and Lutsenko 2009). SXRF is based on the intrinsic fluorescent properties of each element and is therefore element specific. Recent advances in synchrotron technology and optimization of sample preparation have made it possible to image metals in mammalian tissue with submicron resolution.
An overview of the current progress, challenges, and prospects of human biomonitoring and exposome studies
Published in Journal of Toxicology and Environmental Health, Part B, 2019
Mariana Zuccherato Bocato, João Paulo Bianchi Ximenez, Christian Hoffmann, Fernando Barbosa
The term metallome was first introduced by Dr. Robert Williams, similar to the proteome, as the distribution of ions of a chemical element in all compartments of a system (Williams 2001). The term metallomic was incorporated as the study of the metallome. In 2004, Hiroki Haraguchi (2004) provided an alternative definition to “metallome” as metalloproteins or any other biomolecule, and “metallomic” as the study of such biomolecules. Szpunar (2004) defined metallomics as “a comprehensive analysis of the species of a metal or metalloid in biological tissue or fluid”. Chemical species of interest for metallomics include trace element complexes associated with endogenous biomolecules such as organic acids, proteins, fatty acids, and DNA fragments (Szpunar 2004).