Meglumine – Knowledge and References

Meglumine

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Published in William H. Bush, Karl N. Krecke, Bernard F. King, Michael A. Bettmann, Radiology Life Support (Rad-LS), 2017

Bernard F. King

Both iothalamate and diatrizoate are classified as salts, and therefore have to be manufactured in solution with a cation other than hydrogen. Most agents use sodium or meglumine or mixtures of sodium/meglumine for their cation. Meglumine is a 6-carbon sugar with a positive charge, and is better tolerated by the central nervous system and peripheral blood vessels than sodium. Pure sodium salts tend to cause more burning sensation at angiography and tend to result in more CNS toxicity or seizures. Therefore, whenever these agents are used in neurovascular imaging, pure meglumine salts are preferred.

Polyelectrolytic gelatin nanoparticles as a drug delivery system for the promastigote form of Leishmania amazonensis treatment

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Journal Information

Published in Journal of Biomaterials Science, Polymer Edition, 2021

Catarina de Souza, Janicy A. Carvalho, Alexandro S. Abreu, Lucas P. de Paiva, Jéssica A. R. Ambrósio, Milton Beltrame Junior, Marco A. de Oliveira, Josane Mittmann, Andreza R. Simioni

Sousa-Batista et al. (2019) describe the fabrication of polycaprolactone antimony nanoparticles as drug delivery system for Leishmaniasis [22]. The results demonstrated the potential use of these nanoparticles to improve the efficacy of meglumine antimoniate in the treatment of visceral leishmaniasis, indicating their potential as an alternative therapeutic strategy for leishmaniasis infections.