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Epidemiologic Studies
Published in Leon Golberg, Hazard Assessment of Ethylene Oxide, 2017
Direct evidence does not exist that will permit a conclusion that EO is a known human carcinogen. Suggestions of human carcinogenicity are available from four reports (Table 1); one75 from the U.S., two from Sweden74,181 and one from Germany.182 One of the Högstedt et al. reports181 was not a study because no real attempt was made to identify a cohort nor to trace their health experience over time. Rather, this is a case report of three employees who developed blood dyscrasias following exposure at a sterilization plant: one case of chronic myeloid leukemia, another of acute myelogenous leukemia and a third of macroglobulinemia, which is a rare hemopoietic malignancy, not generally classified as a “leukemia”. The authors estimated that only 230 persons had ever worked in exposed areas, and from these only 0.2 cases of leukemia would have been expected. However, as with all reported clusters, these numbers do not lend themselves to rigorous statistical analysis and are of little use in evaluating the specific risks attributable to EO. In addition, the sterilization gas used was a 50-50 mixture of EO and methyl formate, so that workers were exposed to this toxic material as well.
One-step synthesis of magnetically recyclable palladium loaded magnesium ferrite nanoparticles: application in synthesis of anticancer drug PCI-32765
Published in Inorganic and Nano-Metal Chemistry, 2020
Gopala Krishna Dasari, Satyaveni Sunkara, Purna Chandra Rao Gadupudi
The prepared Pd/MgFe2O4 nanocatalyst was applied for the synthesis of 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine an intermediate in preparation of the marketed drug PCI-32765 under the name IMBRUVICA® (Ibrutinib -BTK inhibitor). Our group successfully prepared the drug PCI-32765 by a new synthetic approach.[25] The molecule is biologically active and can be used as an anticancer drug to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström’s macroglobulinemia, a form of non-Hodgkin’s lymphoma by binding the Bruton’s tyrosine kinase(BTK) protein of B cells.
Study of heat sink effect of blood in a bifurcated vessel
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2023
Sidharth Sankar Das, Swarup Kumar Mahapatra
Plasma hyperviscosity syndrome (HVS) is a blood disorder, which is a result of an increase in plasma viscosity that has been reported both in monoclonal and polyclonal immunoglobulin disorders such as Waldenström’s macroglobulinemia, and certain autoimmune diseases (Késmárky et al. 2008). While normal human blood has a plasma viscosity of 1–1.3 cP (centipoise), a person suffering from HVS has a plasma viscosity of 5–7 cP (Castillo et al. 2016).