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COVID-19 pathogenesis and host immune response
Published in Sanjeeva Srivastava, Multi-Pronged Omics Technologies to Understand COVID-19, 2022
Surbhi Bihani, Shalini Aggarwal, Arup Acharjee
National Genomics Data Center-China National Center for Bio-information (CNCB-NGDC) (CNCB-NGDC Members and Partners 2021; S. Song et al. 2020) is preparing an online platform for COVID-19 research to make the published findings available to the researchers, clinicians, and industries. In addition to understanding the current situation, the pertinent situations to be looked into are the long-term effect of COVID-19 on the recovered population, relapse, new variants, and therapeutic strategy for the long run. For reasons as yet unknown, a subset of the population, the effect of COVID-19 is far from over after the viral clearance (Mahase 2020). These patients continue to suffer the debilitating effects of COVID-19, much after being declared free of the virus itself, thus affecting their typical day-to-day functioning. A study on 201 patients suggests that nearly 70% had perturbations in one or more organs four months after their initial symptoms of SARS-CoV-2 infection (Iacobucci 2020; Carfì et al. 2020). Multi-omic studies on long COVID-19 patients and long-term longitudinal studies on completely recovered versus “long COVID” cohorts are the need of the hour to deepen our knowledge of this phenomenon.
Extensions of the Three PDE Chemotaxis Model
Published in William E. Schiesser, Chemotaxis Modeling of Autoimmune Inflammation, 2023
Two case studies of the chemotaxis inflammation model are considered in this chapter: (1) variation/sensitivity of paremeters, and (2) coupling of two models. The changes in the main program and ODE/MOL routines are straightforward and illustrate a methodology for parameter and coupled models development, as well as the extension to other inflammation models that might be suggested as a result of experimental/observational studies, e.g., Covid-19 neurological effects (long Covid).
A detailed review of contrast-enhanced fluorescence magnetic resonance imaging techniques for earlier prediction and easy detection of COVID-19
Published in Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 2023
T. Lurthu Pushparaj, E. Fantin Irudaya Raj, E. Francy Irudaya Rani
‘Long COVID’ is a term used to describe when COVID-19 infections last for more than 80 days in a patient. Survivors with extended COVID are more likely to get infections that spread to various organs, so comprehensive care is required at all times. Currently, the Post-hospitalisation COVID-19 study (PHOSP-COVID), a novel form of Lung MRI technology, has been used to track a huge number of patients with COVID-19 symptoms for years (Rani et al. 2022). Our novel approach provides the first factual indicators of compromised lungs in long-term COVID sufferers, demonstrating how it is not just a case of health anxiety. These results aid the practitioner in comprehending the patient’s cellular functions and adapting effective intervention following COVID-19 recuperation (Chen et al. 2020). MRI analysis is an important option for other imaging modalities to determine COVID-19-infected lung pathology and lung health. MRI is an effective tool for demonstrating either conventional or extra-parenchymal analyses (Litvinukova et al. 2020).
Responsible design and assessment of a SARS-CoV virtual reality rehabilitation programme: guidance ethics in context
Published in Journal of Responsible Innovation, 2022
Merlijn Smits, Geke D. S. Ludden, Peter-Paul Verbeek, Harry van Goor
Long COVID encompasses an array of varying persistent symptoms after COVID-19 infection (The Lancet 2020). Much is still unknown about these symptoms and their treatment. Symptoms include, among others, mental and/or cognitive dysfunction, functional impairment, and fatigue (Van den Borst et al. 2020; Logue et al. 2021). Numerous patients seek the assistance of a physical therapist in their recovery process (Barker-Davies et al. 2020).