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Microencapsulation Of Living Cells and Tissues
Published in Max Donbrow, Microcapsules and Nanoparticles in Medicine and Pharmacy, 2020
Anthony M. Sun, Ivan Vacek, Isaballa Tai
Current therapy for fulminant hepatic failure (FHF) is inadequate, with survival in the range of 10 to 20%. Liver transplantation has recently been performed in patients with FHF, with a success rate of 50%. However, liver transplantation is a formidable procedure, given the problem of rejection and the limited availability of donor livers, and it is associated with major, often lethal complications. Hepatocyte transplantation is potentially a simpler, less hazardous treatment for FHF and permits the storage of hepatocytes for future use. However, the problem of immunological rejection must be solved before the technique can be applied clinically.
Surgical planning for living donor liver transplant using 4D flow MRI, computational fluid dynamics and in vitro experiments
Published in Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 2018
David R. Rutkowski, Scott B. Reeder, Luis A. Fernandez, Alejandro Roldán-Alzate
Liver transplantation is a successful and definitive treatment for patients with liver failure. However, over the last two decades, there has been a short supply of organs from deceased donors. This shortage has motivated the implementation of living donor liver transplantation (LDLT), a therapy that has produced results comparable to traditional cadaveric liver transplantation (Yagi et al. 2004; Kim 2015). In this procedure, a portion of the liver is resected from a living donor and transplanted into a patient with liver failure (Everson et al. 2013). In both the donor and the recipient, the liver tissue can regenerate up to around 80 and 90% of its original size, respectively, after the procedure (Olthoff et al. 2014). However, the central vasculature of the liver cannot regenerate, and therefore the same amount of blood volume must flow through a smaller vascular bed, inevitably leading to higher resistance to blood flow. Such changes in hepatic resistance have been shown to have a role in the liver regeneration process (Yagi et al. 2004). However, the increased resistance also has the potential to induce hyperperfusion and pre-sinusoidal portal hypertension, which can lead to early graft dysfunction and tissue damage due to elevated pressure and wall shear stress (Vasavada et al. 2014; Tong et al. 2015).