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Current Trends in Membrane Science
Published in Mihir Kumar Purkait, Randeep Singh, Membrane Technology in Separation Science, 2018
Mihir Kumar Purkait, Randeep Singh
Autoimmune dysfunction, viral hepatitis, hepatocellular cancer, long duration exposure to toxins (such as alcohol and drugs), or trauma may lead to acute or chronic liver failure. This leads to various life-threatening consequences like hepatic encephalopathy, multiorgan failure, cerebral edema, and severe hypotension. In general, the most common way to restore the functions of an acutely or chronically failed liver is a liver transplant. The problem with this is the same as in other transplant cases, that is, the availability of a suitable donor or organ. Due to this acute shortage of organs, many patients die while waiting for a suitable organ. Therefore, it is important to develop techniques and devices for an artificial liver, which could save the life of a patient until the regeneration of his liver or give him time to wait for the delivery of suitable organ and its successful transplant.
Surgical planning for living donor liver transplant using 4D flow MRI, computational fluid dynamics and in vitro experiments
Published in Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 2018
David R. Rutkowski, Scott B. Reeder, Luis A. Fernandez, Alejandro Roldán-Alzate
Living donor liver transplant has been a successful treatment for liver failure. However, the health and safety of the donor post-transplant are of paramount importance, and there remains insufficient data. Given the difficulty of assessing in vivo liver function and the inability to predict how a specific procedure will alter liver hemodynamics, further work is needed. To facilitate this work, development of new and improved methodologies for individualised prediction of outcomes is needed. This study employed 4D MRI in vivo flow analysis, computational fluid dynamics simulations, a virtual surgery technique that accounts for venous adaptation to increased flow, and in vitro experiments to address this unmet need.