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Recent Developments in Transdermal Drug Delivery Systems Based on an Electrospun Nanofibrous Scaffold
Published in Mangala Joshi, Nanotechnology in Textiles, 2020
A keloid is a firm, abnormal, and fibrous type of scar tissue created by granulation tissue overproduction, which grows beyond the normal limit of cutaneous wound healing. Scientists have used dexamethasone (DEX) to reduce keloid progression by downregulating VEGF expression (endogenous) as well as fibroblast proliferation [53]. Li et al. incorporated DEX into PLGA nanofibers and witnessed a burst release (~40%) in the initial 10 days and a slow release for the next 15 days [54]. Animals treated with DEX-loaded PLGA nanofibrous mats showed a significant reduction in keloids with respect to controls (silicon gel sheet treated). To further improve the efficacy of the system, they also loaded green tea polyphenols into a DEX/PLGA nanofibrous mat. As per histological analyses, a significant improvement in keloid scar reduction was observed.
Medical textiles
Published in Textile Progress, 2020
Prolonged healing or genetic predisposition may result in a hypertrophic or a keloid scar. Both are characterised by the deposition of collagen fibres and bundles within the dermis. Pressure garment therapy is considered an effective strategy for the prevention and management of abnormal scarring and to assist with scar maturation by preventing scar contraction and improving scar biomechanics [444]; this has been the main method of treating hypertrophic scars since the 1970s and can include complicated garments such as gloves [445]. The garments are designed to exert a pressure of approximately 25 mmHg on the underlying tissue in order to exceed the inherent capillary pressure and a soft, flexible and extensible fabric with a thickness of 3.81 mm has been recommended previously [446].
Biomechanical characterization of earlobe keloid by ring suction test
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2020
A. Elouneg, Q. Lucot, E. Veyrat-Durebex, A. Lejeune, J. Chambert, T. Lihoreau, B. Chatelain, G. Rolin, E. Jacquet
Keloid is a fibro-proliferative disease characterized by an overgrowth of scar tissue beyond wound margins. Keloids appear on some specific anatomical sites often believed to be permanently under mechanical load. Besides biological and anatomical factors in keloid growth, the importance of the tissue mechanical environment is well witnessed (Ogawa 2008). Thus, biomechanical studies are still needed to understand the keloid expansion mechanism in order to treat patients or prevent keloid recurrency.