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Carbon Nanotubes for Drug Delivery Applications
Published in Ann Rose Abraham, Soney C. George, A. K. Haghi, Carbon Nanotubes, 2023
Jahanvee Mitra, G. K. P. Srilekha, Nilesh Wagh, Jaya Lakkakula
Earlier, it was discovered that cyclin A2 is a protein responsible for DNA replication, transcription, and regulating the cell cycle. On suppressing cyclin A2 by delivering siRNA, the proliferation of cancer cells can be controlled and apoptosis can be induced. Wang et al. applied the same strategy in their experiment by using functionalized single-walled CNTs mixed with siRNA (f-SWCNTs–siRNA), made out of a complementary strand of that of cyclin A2 producing gene. F-SWCNTs–siRNA of length 50–300 nm were analyzed by FT-IR and XPS and deployed for the treatment of chronic myelogenous leukemia cells (K562). Wang et al. reported that siRNA delivered by f-SWCNT was successful in suppressing cyclin A2 producing genes and eventually breaking the cycle of cancer cell division. This was one of the new strategies brought up by researchers in order to treat leukemia which is predicted to be used extensively in the coming future.71
Nanoparticle–Based RNA (siRNA) Combination Therapy Toward Overcoming Drug Resistance in Cancer
Published in Loutfy H. Madkour, Nanoparticle-Based Drug Delivery in Cancer Treatment, 2022
MDR reversion through the combination of P-gp modulators and cytotoxic drugs has also been achieved with oil nanoemulsions [38], polymeric micelles [84], and liposomes [38,85–87]. A summary of these combinatorial nanoparticles can be found in Table 6.1. Some of these nanoparticle formulations have shown improved efficacy against drug-resistant tumors in vivo. Liang et al., for instance, prepared a stealth liposomal formulation combining vincristine and quinacrine and tested it against a murine model bearing the MDR K562 human chronic myelogenous leukemia. The study showed superior efficacy by the combinatorial liposomal formulation as opposed to the cocktail administration of the free drugs. The quinacrine was found to restore the MDR cells’ response to vincristine, as was confirmed by the increased activity of caspase 9 and 3 [87].
Biomedical Applications of Carbon Nanotubes
Published in Lionello Pogliani, Suresh C. Ameta, A. K. Haghi, Chemistry and Industrial Techniques for Chemical Engineers, 2020
Avinash Kumar Rai, Neha Kapoor, Jayesh Bhatt, Rakshit Ameta, Suresh C. Ameta
Novel TiO /CNT nanocomposites have been prepared by Shen et al.64 2 doped on the carbon paper as the modified electrodes. Then, the redox behavior of the ferricyanide probe and the surface properties of the cancer cells coated on the modified electrodes were investigated using electro-chemical and contact angle measurements. Significantly enhanced electro-chemical signals on the modified electrodes covered with cancer cells have been observed as compared with electrochemical signals on bare carbon paper and nanocomposite modified substrates. It was revealed that different leukemia cells (i.e., K562/ADM cells and K562/B.W. cells) could also be recognized because of their different electrochemical behavior as well as hydrophilic/hydrophobic features on the modified electrodes.
Folate receptor-specific cell-cell adhesion by using a folate-modified peptide-based anchor
Published in Journal of Biomaterials Science, Polymer Edition, 2019
Hiroko Nagai, Wataru Hatanaka, Masayoshi Matsuda, Akihiro Kishimura, Yoshiki Katayama, Takeshi Mori
K562 cells were maintained on suspension culture dishes (Greiner Bio-One, Munich, Germany) in RPMI-1640 medium (FUJIFILM Wako Pure Chemicals) supplemented with 10% (v/v) fetal bovine serum (FBS), 100 U/mL penicillin, 100 μg/mL streptomycin and 0.25 μg/mL amphotericin B (all from Invitrogen, Grand Island, USA). Cells were cultured in a humidified atmosphere containing 5% CO2 at 37 °C. KB cells were maintained on cell culture dishes (Greiner Bio-One, Munich, Germany) in E-MEM medium (FUJIFILM Wako Pure Chemicals) supplemented with 10% (v/v) FBS, 100 U/mL penicillin, 100 μg/mL streptomycin, and 0.25 μg/mL amphotericin B, 2 mM L-Glutamin (FUJIFILM Wako Pure Chemicals). Cells were incubated in a humidified atmosphere containing 5% CO2 at 37 °C.
Green, lipophilic and recyclable catalysts for the aerobic oxidation of alcohols
Published in Inorganic and Nano-Metal Chemistry, 2020
Zahra Mousavi, Bahram Pourgholam, Asghar Zamani, Seyyed Meysam Abtahi Froushani
The K562 erythroleukemia cell line was obtained from Pasteur Institute of Iran. The K562 cells were cultured in RPMI-1640, supplemented with 10% fetal calf serum (FCS) and penicillin plus streptomycin (100 IU/mL and 100 μg/mL, respectively) and cultured in a 5% CO2 humidified atmosphere at 37 °C until near confluence.