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Explore chapters and articles related to this topic
Allogeneic Hemopoietic Stem Cell Transplantation in Animal Models of Autoimmune Disease
Published in Richard K. Burt, Alberto M. Marmont, Stem Cell Therapy for Autoimmune Disease, 2019
IBM-BMT seems to be the best strategy for allogeneic BMT for the following reasons: (i) no GvHD develops even if the T cells are not depleted from the bone marrow; (ii) no graft failure occurs even if the dose of radiation as the conditioning for BMT is reduced to 5Gy × 2; (iii) hemopoietic recovery is rapid; and (iv) the restoration of T cell functions is complete even in donor-recipient combinations across the MHC barriers, since donor-derived stromal cells migrate into the thymus where they are engaged in positive selection.60 This “IBM-BMT” is therefore applicable to humans, since intraosseous (i.o.) infusion (IBM-injection) is an established method for administering fluids, drugs, and blood to critically ill patients, and particularly infants. Indeed, Hagglund et al have recently compared the effectiveness of i.o. infusion with that of i.v. infusion in human allogeneic BMT;62 they have concluded that allogeneic BMT can be safely performed by i.o. infusion, but the incidences of acute and chronic GvHD, transplantation-related mortality, and survival rates are similar. However, they aspirated the donor BMCs from the iliac bones and infused these BMCs into the iliac bones of the recipients.
Pills
Published in Jeffrey T. Solate, Dictionary of Pharmaceutical Dosage Forms, 2020
Description: Intraosseous infusion is the process of injection directly into the marrow of the bone. The needle is injected through the bone’s hard cortex and into the soft marrow interior. Often the antero-medial aspect of the tibia is used because it lies just under the skin and can easily be palpated and located.
Emergency provider preference for powered intraosseous devices and satisfaction with features improving safety, reliability, and ease-of-use
Published in Expert Review of Medical Devices, 2023
Drew Jones, Kimberly Alsbrooks, Andrew Little
Intraosseous (IO) access is an important method for achieving rapid vascular access during emergent situations and is recommended by the American Heart Association and European Resuscitation Council when intravenous (IV) access is unobtainable [1,2]. IO access is achieved using a manual, semiautomatic (i.e. spring-loaded), or battery-powered IO system, and studies comparing these systems suggest powered IO devices are superior with respect to ease-of-use, first-attempt success rates, and user preference [3]. Despite the suggested superiority of powered IO systems, these instruments have been subject to minimal innovation since their introduction to address common challenges experienced during emergent situations.