Intraoperative radiation therapy

Kilovoltage X-ray beam dosimetry and imaging

Published in Indra J. Das, Radiochromic Film, 2017

Intraoperative radiation therapy (IORT) involves the application of high doses of ionizing radiation to the tumor bed at the time of surgery such as for breast cancer patients [9,16]. There are several IORT units that deliver kilovoltage X-ray beams such as the Intrabeam (Carl Zeiss AG, Germany) with X-ray beams energies of up to 50 kVp.

Minimizing re-excision after breast conserving surgery – a review of radiofrequency spectroscopy for real-time, intraoperative margin assessment

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Journal Information

Published in Expert Review of Medical Devices, 2021

Vincent J. Reid, Jeffrey S. Falk, Alice M. Police, Calvin A. Ridgeway, Lisa L. Cadena, Stephen P. Povoski

Avoiding re-excision for patients receiving Intraoperative Radiation Therapy (IORT) is especially important. IORT strives to complete surgery and radiation in the same setting, all while patient is under anesthesia. The method prevents weeks of daily whole breast radiation therapy after BCS. One risk of IORT is that lumpectomy margin status is unknown at time of treatment. In the event final pathology reports a positive margin in a patient who has received IORT, it is necessary to return for a re-excision and then convert to traditional whole breast radiation therapy. Recent data in this population reported a 73% reduction in re-excision from 10.4% to 2.8%, when the device is used, suggesting the device provides considerable additional benefit for breast cancer patients in the setting of IORT [43].

Intraoperative radiation therapy

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Kilovoltage X-ray beam dosimetry and imaging

Minimizing re-excision after breast conserving surgery – a review of radiofrequency spectroscopy for real-time, intraoperative margin assessment