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Viral and Bacterial Infection Prevention Through Intentional Design
Published in AnnaMarie Bliss, Dak Kopec, Architectural Factors for Infection and Disease Control, 2023
Debra Harris, Denise N. Williams
For example, hydrogen peroxide is a chemical compound used as an oxidizer, bleaching agent, and as an effective disinfectant for building surface materials, furniture, and equipment.66–69 Hydrogen peroxide vapor (HPV) disinfection systems are specifically being used to disinfect whole rooms to reduce patient exposure to hospital pathogens in the health care environment. When testing the efficiency of hydrogen peroxide in improving disinfection of intensive care unit rooms contaminated with multidrug-resistant organisms after patient discharge, HPV was determined effective when aerosolized hydrogen peroxide was combined with peracetic acid.70 However, it must be considered that hydrogen peroxide and peracetic acid are corrosive and, over time, may damage some plastic and polymer surface materials. Another limitation of the HPV system is the 2 to 2.5 hours required to disinfect a room. Thus, environmental services may disregard HPV as an option due to time constraints.
Other Reactions from Gloves
Published in Robert N. Phalen, Howard I. Maibach, Protective Gloves for Occupational Use, 2023
T. Bullock, A. Sood, J.S. Taylor
The COVID-19 pandemic has brought a new focus on the sterilization of medical equipment with ozone, ethylene oxide, air ionization, hydrogen peroxide vapor, and UV rays.131,132 Hydrogen peroxide vapor is being used to sterilize used N95 masks and face shields at many hospitals.133 Recently, ETO treatment of used and expired N95 respirators showed unchanged fitted filtration efficiencies, suggesting that used or expired N95 respirators treated with ETO can be acceptable alternatives when new N95 respirators are unavailable.134 Skin reactions should be further investigated as changes in sterilization methods and techniques occur due to COVID-19.60
Disinfecting Efficacy of an Ozonated Water Spray Chamber: Scientific Evidence of the Total and Partial Biocidal Effect on Personal Protective Equipment and in Vitro Analysis of a Viral Experimental Model
Published in Ozone: Science & Engineering, 2023
Fabricia Oliveira, Laerte Marlon Conceição Dos Santos, Eduardo Santos da Silva, Leticia de Alencar Pereira Rodrigues, Paulo Roberto Freitas Neves, Greta Almeida Fernandes Moreira, Gabriela Monteiro Lobato, Carlos Nascimento, Marcelo Gerhardt, Alex Alisson Bandeira Santos, Luis Alberto Brêda Mascarenhas, Bruna Aparecida Souza Machado
New devices have been developed as an alternative technology to overcome these limitations, and these also occupy an important position in the control of microorganisms (Jinadatha et al. 2015). A chamber-type air disinfection system using a UVC LED matrix for nebulization has been effective in inactivating Escherichia coli, Salmonella typhimurim, Listeria monocytogene, Staphyloccocus aureus, Aspergillus, Alternaria japonica, and bacteriophages (D. Kim and Kang 2018). A chamber system with an aerosolized solution including hypochlorite, designed by Ishikawa et al. (2019), has been shown to be capable of inactivating Bacillus subtilis spores. The combination of 80 ppm with 1% hydrogen peroxide vapor in a test chamber reached a high level of disinfection (>6 log10) of resistant S. aureus methicillin, vancomycin-resistant Enterococcus, E. coli, Pseudomonas aeruginosa, Clostridium difficile, and B. subtilis spores over a period of 30 to 90 minutes (Zoutman, Shannon, and Mandel 2011).
Evaluation of surface disinfection methods to inactivate the beta coronavirus Murine Hepatitis Virus
Published in Journal of Occupational and Environmental Hygiene, 2022
R. L. Hardison, S. W. Nelson, D. Barriga, N. Feliciano Ruiz, J. M. Ghere, G. A. Fenton, D. J. Lindstrom, R. R. James, M. J. Stewart, S. D. Lee, M. W. Calfee, S. P. Ryan, M. W. Howard
Hydrogen peroxide solutions have been tested for virucidal effect against multiple agents, and are included into antimicrobial mouthwash formulation, hydrogen peroxide vapor decontamination of N95 respirator masks, and many other disinfection methods (Bidra et al. 2020). Previous studies show variable effectiveness of peroxide solutions with respect to the formulation and virus tested. While hydrogen peroxide (0.5% hydrogen peroxide solution containing surfactants) was effective against human coronavirus 229E (>4 log10 reduction) with a 1-min contact time (Omidbakhsh and Sattar 2006), when tested against SARS-CoV-2, shorter contact times (30 sec) were less effective (<2.5 log10 reduction, 0.1% hydrogen peroxide) than longer contact times (1 minute, >4.5 log reduction) (Gerlach et al. 2020). In the present study, testing with 0.39% hydrogen peroxide (Peroxide Multi-Surface Cleaner) achieved limited efficacy against MHV (1.97 ± 0.78 log10 reduction on SS) with a 30-sec contact time (Figure 3). While longer contact times were not tested, it is likely that longer times may increase efficacy against MHV. Taken together, these studies highlight the importance of empirically determining contact time for surface disinfectants specific to the viral agent and material to be treated.