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Naturally Occurring Polymers—Animals
Published in Charles E. Carraher, Carraher's Polymer Chemistry, 2017
In the laboratory the immortal cell lines are those derived from cancer. The most famous is the HeLa cancer cells that many of us use as one of the cell lines tested against various anticancer agents. The HeLa cells are derived from Henrietta Lacks, a black woman, who died from cervical cancer. They are so strong that they are known to invade other cell lines, both healthy and other cancer cell lines giving contaminated or mutated cell lines. HeLa cells have good telomerase levels. If antisense RNA is added to HeLa cells so that the RNA contains the message opposite to the ordinary RNA in the telomerase, the effect is to block the telomerase and the HeLa cells are no longer immortal and die after about 25 replications.
Evaluation of a single amino acid substitution at position 79 of human IFN-α2b in interferon-receptor assembly and activity
Published in Preparative Biochemistry and Biotechnology, 2019
Samira Talebi, Alireza Saeedinia, Mehdi Zeinoddini, Fathollah Ahmadpour, Majid Sadeghizadeh
In this study, the function and structure of human IFNα are considered. For saving time and money as well as targeting to precise results, novel effective mutants were designed using bioinformatics tools in silico, then, the most effective one was selected and prepared in recombinant technique, the modified nucleic acid sequence was introduced to CHO cell line, modified IFN-α2b protein was purified from cell culture and its activities were assessed in HeLa cell line and vesicular stomatitis virus (VSV). HeLa is a cell line derived from cervical cancer cells and it is the most commonly used human cell line in scientific researches.[47] Vesicular stomatitis virus is a member of the Rhabdoviridae family. The wild-type (WT) virus grows to high titers in a variety of tissue culture cell lines. Therefore, VSV is used as an excellent biological tool to study basic biological processes and functions.[48]
Inhibition of Proliferation of HeLa Cells by Pulsed Electric Field Treated Mentha piperita (Mint) Extract
Published in IETE Journal of Research, 2022
Thulasidas Jeya Shree, Varadarajan Gowri Sree, Sadasivam Poompavai, Elisabetta Sieni, Paolo Sgarbossa, Ignacio Camarillo, Raji Sundararajan
SiHa, HeLa, and C33A are the cervical cancer cell lines widely used for cervical cancer research. HeLa cells were the first immortal human cells to be cloned. HeLa cells comprise an immortalized, continuously cultured cell line of human cancer cells. Jain et al. reported cell viability of about 87% against human cervical cancer cell line HeLa after treatment with 100 µg/ml of methanolic M. piperita leaf extract for 6 hours [39]. These studies show us that mentha extract has anti-cancer property against cervical cancer.