HTLV

HTLV

Human T-lymphotropic virus (HTLV) is a type of retrovirus that infects T-cells and can cause a rare strain of leukemia to develop. Specifically, Human T-cell lymphotropic virus type-1 (HTLV-1) is a complex retrovirus that contains two copies of its genomic RNA and infects multiple cell types, but only induces cell transformation in T-lymphocytes. HTLV-I infection is associated with a variety of diseases, including adult T-cell leukemia, as well as inflammatory diseases such as uveitis and arthropathy.From: Dictionary of Biomedical Science [2019], Overview of biological mechanisms of human carcinogens [2019], Image Principles, Neck, and the Brain [2019]

Evidence for a Role of Infections in the Activation of Autoreactive T Cells and the Pathogenesis of Autoimmunity

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Published in Richard K. Burt, Alberto M. Marmont, Stem Cell Therapy for Autoimmune Disease, 2019

J. Ludovic Croxford, Stephen D. Miller

Although EBV is rarely found in MS lesions, serological studies have found higher titers of EBV-specific antibodies in MS patients compared to controls.38 Human T-lymphocyte virus 1 (HTLV-1) is a retrovirus associated with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a human demyelinating disease of the CNS.39 However, many HTLV-1 seropositive individuals are asymptomatic, suggesting that genetic predisposition and immunological dysfunction may also play a role in HTLV-1-induced disease. Although HTLV-1 has been detected in MS patients, this has not been confirmed in other studies.40,41

Overview of biological mechanisms of human carcinogens

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Published in Journal of Toxicology and Environmental Health, Part B, 2019

Nicholas Birkett, Mustafa Al-Zoughool, Michael Bird, Robert A. Baan, Jan Zielinski, Daniel Krewski

Human T-cell lymphotropic virus type-1 (HTLV-1) is a complex retrovirus that contains two copies of its genomic RNA which infect multiple cell types but only induce cell transformation in T-lymphocytes. HTLV-1produces adult T-cell lymphoma/leukemia.

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Evidence for a Role of Infections in the Activation of Autoreactive T Cells and the Pathogenesis of Autoimmunity

Overview of biological mechanisms of human carcinogens