HGFR

HGFR

Evaluating the Interactions of Silver Nanoparticles and Mammalian Cells Based on Biomics Technologies

Published in Huiliang Cao, Silver Nanoparticles for Antibacterial Devices, 2017

The ‘Regulation of actin cytoskeleton’ and ‘Signalling of hepatocyte growth factor receptor’ pathways were related to cytoskeletal function. Slingshot protein phosphatase 2 (SSH2) is a member of the SSH family and can activate cofilin, causing abnormal migration behaviours of epidermal cells (Kligys et al. 2007). CRK is an adaptor protein, whose genetic knockdown can result in cytoskeleton disorder and cellular boundary damage (Birge et al. 2009). The down-regulation of SSH2 mRNA and CRK protein might suggest that Ag NPs could impair the cytoskeleton of HDFs.

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR

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Journal Information

Published in Green Chemistry Letters and Reviews, 2021

Essam M. Eliwa, Marcel Frese, Ahmed H. Halawa, Maha M. Soltan, Larissa V. Ponomareva, Jon S. Thorson, Khaled A. Shaaban, Mohamed Shaaban, Ahmed M. El-Agrody, Norbert Sewald

The most potent one against KB-3-1 and A549 cell lines (Table 2), 4e showed 1.2 and 2.5-fold inactivation toward VEGFR-2 and EGFR, respectively. Moderate activities were also obtained by 5e against the examined kinases. Regarding COVID-19, in silico studies have predicted higher affinity between the viral spike glycoprotein (S) and the inhibitors of the hepatocyte growth factor receptor (HGFR/c-MET), VEGFR and EGFR [56]. Consequently, exploring more agents against the above receptors is more than welcome.

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Evaluating the Interactions of Silver Nanoparticles and Mammalian Cells Based on Biomics Technologies

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR