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Delivery of Herbal Cardiovascular Drugs in the Scenario of Nanotechnology: An Insight
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Kumar Anand, Subhabrata Ray, Md. Adil Shaharyar, Mahfoozur Rahman, Rudranil Bhowmik, Sanmoy Karmakar, Monalisha Sen Gupta
Many herbs are found to contain potent cardioactive glycosides having serious cardiovascular effects showing positive inotropic actions. Digitalis purpurea is one of the famous herbs containing cardioactive glycosides used successfully for cardiac arrhythmia leading to CHF since many decades. Digoxin and Digitalis are the responsible cardioactive glycosides found in Digitalis pupurea. Digitalis lanata contains only digoxin. As a drawback of the drug, the therapeutic index of digitalis and digoxin is very low which makes the dose of the drug a subject of concern (Amine et al., 2016).
Ionic Liquids in Sustainable Carbohydrate Catalysis
Published in Pedro Lozano, Sustainable Catalysis in Ionic Liquids, 2018
Pilar Hoyos, Cecilia García-Oliva, María J. Hernáiz
Enzyme-catalyzed glycosylations reactions are becoming a very promising alternative to traditional chemical strategies, as the high selectivity displayed of enzymes allows to avoid many protection/deprotection steps. Glycosidases (E.C. 3.2.1) make up the group of enzymes commonly employed in oligosaccharides synthesis. In nature, this class of enzymes catalyzes the hydrolysis of glycosidic bonds, but, under appropriate conditions, many of them are able to mediate the synthesis of glycosidic linkages. In general, they are easily available enzymes, tolerant to organic solvents, present a broad range of substrates, and usually display high stereospecificity. Although the development of efficient enzymatic synthesis still remains challenging, different approaches have achieved desired glycosides in excellent yields and selectivities (Farran et al., 2015).
Bioactive Compounds in agricultural and Food production Waste
Published in Quan V. Vuong, Utilisation of Bioactive Compounds from Agricultural and Food Waste, 2017
Nenad Naumovski, Senaka Ranadheera, Jackson Thomas, Ekavi Georgousopoulou, Duane Mel lor
Glycosides contribute to the flavor, taste, color and quality of a number of plant- derived foods. For example, the most widespread anthocyanin which contributes color to fruits is cyanidin-3-glucoside (Fig. 3) (Kong et al. 2003, Shahidi and Ambigaipalan 2015). Additionally, therapeutic properties of glycosides include anticancer effects (Newman et al. 2008), expectorant, sedative, antidepressant, anticonvulsant activities and effect on the central nervous system (Fernández et al. 2006, Kabera et al. 2014, Wang et al. 2016). Glycosides can also be recovered from similar techniques used in isolation of alkaloids with water, methanol or ethanol used as the solvent for extraction (Brito-Arias 2007).
Recent advances of polymer based nanosystems in cancer management
Published in Journal of Biomaterials Science, Polymer Edition, 2023
Chetan Janrao, Shivani Khopade, Akshay Bavaskar, Shyam Sudhakar Gomte, Tejas Girish Agnihotri, Aakanchha Jain
Natural polymers are the best alternative for creating the nanocarrier system, which has gain significant attention from pharmaceutical industries in recent years. Albumin, alginate, chitosan, hyaluronic acid, and hydroxyapatite are a few examples of natural polymers that are employed to create nanosystems [18]. These natural polymers offer many advantages such as being biocompatible, biodegradable, nontoxic, and nonimmunogenic [19]. Additionally, natural materials have functional groups easy to modify them for conjugation with drug molecules, targeting ligands, or the creation of copolymers [20]. Moreover, they could have certain protein binding sites and other biochemical signals that could help with tissue engineering or localized administration [21]. Natural polymers are produced by bacteria, fungi, plants, and mammals. Polysaccharides and protein-based polymers are the main two primary categories. Both can form scaffolds as functional extracellular matrix (ECM). This will result in targeted drug delivery with good loading efficiency [19, 22,23]. In context with polysaccharides, they are long chains of polymeric carbohydrates composed of simple monosaccharide repeating units linked by glycosidic bonds. It contained more than 10 simple monosaccharide units. Mainly it is obtained from plants, algae, mammals, and microbes [24,25]. Natural tissues are typically the source of protein-based polymers. They are often both biocompatible and biodegradable and deteriorate naturally. Collagen, albumin, and gelatin are the three proteins that are most frequently employed in nanosystems for drug delivery systems [26].
Application of a binary mixture of bio-extract on organic cotton fabric
Published in The Journal of The Textile Institute, 2022
M. Janarthanan, Subrata Das, M. Jayapradeep, S. SumaiyaZainab, S. Venkatesh
Carotenoids compound plays an important role in improving human health and reducing the risk of chronic diseases. The main characteristics are anti-cancer, antioxidant, and antibacterial activities. Glycosides have properties such as anti-microbial, anti-inflammatory, anti-cancer, and anti-tumor activity, anti-allergic, and anti-platelet. They are used as antibiotics in the medical field. Anthraquinones have anti-oxidant, anti-microbial, anti-tumor, and anti-inflammatory properties. It is used for the treatment of autoimmune diabetes and wound healing. Saponins have properties such as anti-microbial, anti-inflammatory, anti-cancer, and anti-tumor activity, anti-allergic, anti-platelet, anti-carcinogenic, and anti-hepatic. It is used to protect from skin aging. Alkaloids have properties such as anti-microbial, anti-inflammatory, anti-cancer, and anti-tumor activity, anti-allergic, and anti-platelet. It has the properties of curing wounds and destroying bacterial formation. Ursolic acid is an indispensable part of the human diet and also a medicinal plant. It has antioxidant and anti-tumor activities. It is also used to treat cancer cells.
Phytochemistry, ethnomedicinal uses and pharmacological activity of Diodia scandens; a review of current scientific literature
Published in Egyptian Journal of Basic and Applied Sciences, 2022
Abubakar Sadiq Wada, Sa’adatu Muhammad Julde, Safiya Bala Borodo, Mubarak Hussaini Ahmad, Sani Malami, Abdullahi Hamza Yaro
Simple chemical screening tests are usually performed to ascertain the phytochemicals present using appropriate chemical reagents. Tannins which are found to be present and having astringent and detergent properties could be responsible for its activity when used for diarrhea and dysentery [29,30]. Saponins have been reported to poses anti-inflammatory, antifungal, anti-parasitic, anti-tumor and anti-viral activities were as such could be responsible for its observed usefulness in traditional medicine. Naturally occurring cardiac glycosides have proven useful in the treatment of various heart diseases [30].