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Diabetes and Antidiabetic Therapy: Control of Glucose
Published in Richard J. Sundberg, The Chemical Century, 2017
The fibrates are believed to be activators of PPAR-α, one of a family of transcription factors that regulate lipid and carbohydrate metabolism. PPAR-α is particularly associated with the liver, muscle, and heart. The fibrates reduce triglyceride levels and modestly improve HDL/LDL ratios. They also appear to improve the resistance of the endothelium to inflammation and plaque formation.
Estimation of non-alcoholic steatohepatitis (NASH) disease using clinical information based on the optimal combination of intelligent algorithms for feature selection and classification
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2023
The extracted features can be categorized into two groups: demographic information (including BMI, sex, age, statin value, drugs taken for cholesterol and glyceride reduction, Colestilan as hyperphosphatasemia and hypercholesterolemia treatment, Ezetimibe as a blood cholesterol drug index, Fibrate, which is used to reduce cholesterol and triglycerides, Eicosapentaenoic acid (EPA) as an Omega-3 fatty acid, and lipid-lowering agents, which are agents for consuming drugs for cholesterol reduction, blood fat reduction, or anti-fatty blood) and blood test parameters (including γ-GTP, Glutamate-Pyruvate Transaminase (GPT), Creatinine (Cre), HbA1c, Total cholesterol level (TC), Total level of triglyceride (TG), HDL, LDL, and lipoprotein level (Lp(a)) from blood serum). Table 1 provides definitions of features and their variations. It is important to note that the dataset was initially rescaled to eliminate biases in classification algorithms. A scaling procedure was applied, and the dataset was normalized in the range of to provide an appropriate condition for the chosen methods.
Association of serum levels of p,p’- Dichlorodiphenyldichloroethylene (DDE) with type 2 diabetes in African American and Caucasian adult men from agricultural (Delta) and non-agricultural (non-Delta) regions of Mississippi
Published in Journal of Toxicology and Environmental Health, Part A, 2019
Edward C. Meek, Dana Dale Jones, J. Allen Crow, Robert W. Wills, William H. Cooke, Janice E. Chambers
Univariable logistic regression analysis of the association of T2D with demographic, clinical, and pesticide-related variables collected or determined as part of this investigation is shown in Table 5. Values for HDL cholesterol, LDL cholesterol, and triglyceride levels combined with statin, niacin, or fibrate usage were utilized to construct the categorical variables HDL group, LDL group, and triglyceride group presented in this analysis. The variables age, race, Delta residence, tobacco use, and Greenville Clinic patient all displayed P values ≥0.25 and not included in the original multivariable analysis. DDE and trans-nonachlor are included in the univariable analysis even though it was planned to force them into the basic multivariable model for analysis.