Endoglin

Endoglin

Endoglin is a transmembrane glycoprotein that is over-expressed in the vasculature of tumors and other tissues undergoing vascular remodelling. It forms a complex with Alk1 and has a joint function of BMP/flow receptor, regulating vascular morphogenesis through vessel stabilization.From: Nanotechnology for Cancer Therapy [2006], Review on the current treatment status of vein of Galen malformations and future directions in research and treatment [2021]

RGD-Modified Liposomes for Tumor Targeting

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Published in Mansoor M. Amiji, Nanotechnology for Cancer Therapy, 2006

P. K. Dubey, S. Mahor, S. P. Vyas

Endoglin (CDI05) is a transmembrane glycoprotein, over-expressed in the vasculature of tumors and other tissues undergoing vascular remodelling (Miller et al. 1999). Differential up-regulation of endoglin presents an interesting opportunity to the selective delivery of cytotoxic molecules to the target endothelial cells. Several monoclonal antibodies specific for human endoglin have been produced (Seon et al. 1997). Radioiodinated monoclonal antibodies (10 μi) given to tumor-bearing animals significantly inhibited the tumor growth. This indicates the clinical potential of cytotoxic agent targeting using endoglin (Tabata et al. 1999).

Review on the current treatment status of vein of Galen malformations and future directions in research and treatment

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Published in Expert Review of Medical Devices, 2021

Panagiotis Primikiris, Georgios Hadjigeorgiou, Maria Tsamopoulou, Alessandra Biondi, Christina Iosif

Baeyens et al. [172] reported that fluid shear stress potentiates BMPs to activate Alk1 signaling, with enhanced association of Alk1 and endoglin. Alk1 is required for BMP9 and flow responses, while endoglin is required for enhancement by flow [172]. Impaired Alk1 signaling results in the formation of vascular shunts, specifically in regions of high blood flow [172]. Overall, Baeyens et al. [172] reported that Alk1-endoglin complex has a joint function of BMP/flow receptor, regulating vascular morphogenesis through vessel stabilization. Further research on the mechanism through which flow acts on these receptors enhancing BMP signaling may identify new targets of therapy through the understanding of vascular mechanotransduction [172].

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RGD-Modified Liposomes for Tumor Targeting

Review on the current treatment status of vein of Galen malformations and future directions in research and treatment