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Pesticides and Chronic Diseases
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 4, 2017
William J. Rea, Kalpana D. Patel
Lindane: Lindane (Figures 7.8 and 7.9) is an insecticide used as a fumigant and for the control of body lice. It is commonly used for sheep dipping in the wool industry. Lindane accumulates in plants and animals. It is the gamma isomer of hexachlorocyclohexane (BHC). Lindane is one of eight isomers of BHC, and it is the most toxic. Technically, BHC contains 12%–15% lindane, which at one time was found in the blood of most of the U.S. population. It is found in workers who manufacture lindane.83,119–121 Lindane has been found in the blood of eight infants who were treated with a total body application of 1% lindane lotion.122 The average half-life for one application is 21 hours, but it accumulates in fat and may last much longer in the chemically sensitive. The ratio of fat concentration to blood (serum) for BHC isomers is 220:1.121 Lindane is metabolized by oxidation and dehalogenation, to a series of chlorinated phenols similar to HCB. Overload is associated with neurological abnormalities, including EEG changes, muscular jerking, and emotional lability.123 Aplastic anemia occurred after chronic exposure from vaporizers.124,125 Lindane was probably responsible for a mass-poisoning episode when it was absorbed dermally, producing mental confusion, weakness, anemia, convulsions, and death in six individuals (Table 7.13).126
Drug Side Effect Frequency Mining over a Large Twitter Dataset Using Apache Spark
Published in Saravanan Krishnan, Ramesh Kesavan, B. Surendiran, G. S. Mahalakshmi, Handbook of Artificial Intelligence in Biomedical Engineering, 2021
Dennis Hsu, Melody Moh, Teng-Sheng Moh, Diane Moh
Adderall is a stimulant used in the treatment of ADHD. Adderall is composed of two amphetamine salts, dextroamphetamine and amphetamine, which are controlled substances due to being highly addictive; thus, it is not surprising that they cause addictive behavior. Similarly, Vyvanse is also an amphetamine salt, lisdexamfetamine, and is also highly addictive. Both Adderall and Vyvanse cause irritability, anxiety, and emotional lability, a.k.a. mood swings. This may occasionally cause those taking Vyvanse to feel high.
UDC: 612.084:636 the effect of 2-oxoindoline-3-glyoxylic acid derivatives on animals’ behavioral and autonomic reactions in the open field test
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Ruslan V. Lutsenko, Oleksiy V. Storozhenko, Antonina H. Sydorenko, Svetlana Yu. Chechotina, Olga A. Lutsenko
Considering the obtained results, it can be suggested that the presence of sedative and anxiolytic activity in the compounds allows positioning them for potential use in the treatment of anxiety disorders, anxiety-neurotic states (emotional lability, memory impairments, decreased concentration and attention), restlessness, fear, obsessive states, as well as for the prevention of stress-related conditions.