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Nanodevices for Drug Delivery Systems
Published in Suvardhan Kanchi, Rajasekhar Chokkareddy, Mashallah Rezakazemi, Smart Nanodevices for Point-of-Care Applications, 2022
Kajal Karsauliya, Sheelendra Pratap Singh, Manu Sharma
The system of nanomaterials used for drug delivery (nano-drug delivery systems) is the category of nanomaterials capable of enhancing the solubility and stability of drugs, as well as cell or tissue uptake rate, and decreasing the enzyme degradation, consequently improving the safety and efficacy of drugs. As an efficacious method to improve drug delivery, nano-drug carriers have evolved as an area of high interest in the field of biomedicine and pharmacy. Depending on the composition of nanomaterials being used for constructing the nano-drug delivery system, the nanomaterials are classified into organic, inorganic, and composite materials, for example, liposomes, polymer micellar co-delivery system, dendritic macromolecules, metal nanomaterials, and inorganic non-metallic nanomaterials (Figure 13.1) [20].
Carbon Fibers
Published in Chander Prakash, Sunpreet Singh, J. Paulo Davim, Advanced Manufacturing and Processing Technology, 2020
Suneev Anil Bansal, Javad Karimi, Amrinder Pal Singh, Suresh Kumar
Drug delivery is a very attractive method in medicine that refers to the transfer of a medicinal compound in the existing body to induce a desired therapeutic effect with the least side effects. Drug connection to the carrier, transmission drug carrier in the body, and the precise, controlled, and targeted drug delivery, for example, in cancerous tissues are very important [45]. CFs, carbon nanotubes, and other nano- or microcarbon structures have good mechanical properties such as quite great surface area, high tensile strength, high electrical conductivity, high thermal conductivity, and respectable flexibility, which are very useful to drug delivery (Figure 10.5) [46].
An Overview of Polyelectrolyte-Based Nanoplex
Published in Satish A. Dake, Ravindra S. Shinde, Suresh C. Ameta, A. K. Haghi, Green Chemistry and Sustainable Technology, 2020
Swati G. Talele, Shweta S. Gedam, Akshada A. Bakliwal
Liposomes: These are a minute spherical sac of phospholipid molecules which encloses a water droplet to carry drugs or other substances into the tissues. Liposomes consist of at least one lipid bilayer. It is defined as the small artificial vesicles ranging from the 50–100 nm made up of phospholipids. They are used as a drug carrier because they have the ability to prevent drug degradation, minimizes side effects and acts as a targeted drug delivery system. Liposomes mostly used in the treatment of ocular diseases and transdermal drug delivery [26].
Keratin-tannic acid complex nanoparticles as pH/GSH dual responsive drug carriers for doxorubicin
Published in Journal of Biomaterials Science, Polymer Edition, 2021
Jinsong Du, Lijuan Wang, Xiao Han, Jie Dou, Jiang Yuan, Jian Shen
Drug carriers can effectively deliver drugs to tumor sites. This therapeutic strategy with high efficiency and low side effects can controllably deliver drugs. Thus, the preparation of a safe and non-toxic drug carrier has drawn extensive attention [32, 33]. In the study, a drug carrier was prepared using keratin and TA. KNPs were formed mainly based on the hydrogen bonding between the phenolic group of TA and the carboxyl group of keratin [21]. In the whole procedure, no toxic crosslinkers were used. The successful preparation of KNPs was confirmed by FTIR spectroscopy (Figure 2). The absorption peaks at 1655 and 1539 cm−1 were ascribed to amide I and amide II of keratin. The amide I was mainly caused by the stretching vibration of the carbonyl group (C = O) in the phthalimide group of the protein, and the amide II mainly resulted from the bending vibration of N–H (60%) and the stretching vibration of C–N (40%) in the amino compound. Furthermore, the peaks at 1709 and 1330 cm−1 were assigned to the stretching of the benzene ring C = C structure and the deformation (O-H) of phenolic in TA, respectively [34]. All these results demonstrated that the KNPs were obtained successfully.
Microbes induced biofabrication of nanoparticles: a review
Published in Inorganic and Nano-Metal Chemistry, 2020
Devendra Kumar Golhani, Ayush Khare, Gopal Krishna Burra, Vikas Kumar Jain, Jagannadha Rao Mokka
The biosynthesized NPs have multiple industrial applications in almost all sectors such as energy, medical, agriculture, pharmaceuticals, electronics, etc. Medical applications are very much remarkable as bionanoparticles are less toxic than NPs synthesized through other physical/chemical methods. It includes drug carriers for targeted delivery, cancer treatment, gene therapy, DNA analysis and repair, antibacterial agents, biosensors, enhancing reaction rates, separation science, and magnetic resonance imaging (MRI), etc. In the field of agriculture, bionanoparticles contribute in improving plant disease resistance, control of nutrients, detection of mycotoxins in food, monitoring of water quality, biopesticides in controlling target diseases of pests and insect origin, and nano-fertilizers for sustainable development of crops.[189,190]
Design and evaluation of sustained-release lipid-PLGA hybrid nanoparticles for enhanced anticancer efficacy of 5-fluorouracil
Published in Particulate Science and Technology, 2023
Safiullah Khan, Asadullah Madni, Muhammad Naeem Aamir, Shahzeb Khan, Fiaz-ud-Din Ahmad, Abdul Basit, Nasrullah Jan, Hassan Shah, Afifa Shafiq, Maryam Anwar
Chemotherapy is an effective approach to treat cancer but restricted because it may cause serious side effects due to its toxic effects on normal tissues (Wang 2020). Nanotechnology can overcome the limitations of conventional chemotherapy (Horo et al. 2019). Nanotechnology has revolutionized drug delivery systems by enhancing the solubility, stability, and bioavailability of drugs. In the case of colon cancer treatment, nanoparticulate drug-delivery systems are considered as a promising therapeutic modality (Haggag et al. 2021). There are several types of nanoparticulate drug delivery systems, including polymeric nanoparticles, lipid-based nanoparticles, and inorganic-based nanosystems. Each type of system has unique properties that can be tailored to deliver drugs to specific cells or tissues (Ibrahim et al. 2022). Among the various kinds of nanocarriers, polymeric nanoparticles and liposomes have been widely used as drug carriers. Polymeric-based nanosystems are one of the most widely studied types of drug delivery systems. They are composed of synthetic or natural polymers and can be designed to release drugs in a controlled manner. Polymeric-based nanosystems have several advantages, including biocompatibility, biodegradability, and low toxicity (Haggag et al. 2020). Polymeric nanoparticles owing to their high structural integrity, controlled release capability, and stability have been widely used but limited by their poor biocompatibility. Likewise, liposomes have superior biocompatibility, promising pharmacokinetic profile, long circulation time, and easy surface modification but it also has some drawbacks such as instability during storage, low encapsulation of water-insoluble drugs, and burst release of the drug (Gu et al. 2017).