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List of Chemical Substances
Published in T.S.S. Dikshith, and Safety, 2016
Disulfoton is highly toxic to animals and humans by all routes of exposures, namely, by dermal absorption, through ingestion, and inhalation by the respiratory route. The symptoms of poisoning include blurred vision, fatigue, headache, dizziness, sweating, tearing, and salivation. It inhibits cholinesterase and affects the nervous system function. It does not cause delayed neurotoxicity. Prolonged period of exposures to high concentrations of disulfoton cause harmful effects to the nervous system with symptoms such as narrowing of the pupils, vomiting, diarrhea, drooling, difficulty in breathing, lung edema, tremors, convulsions, coma, and death. Disulfoton causes no mutagenic or teratogenic effects in laboratory animals. There are no reports indicating that disulfoton causes cancer in animals or humans. The DHHS, the IARC, and the US EPA have not classified disulfoton as to its ability to cause cancer.
Risk assessment of benzalkonium chloride in cosmetic products
Published in Journal of Toxicology and Environmental Health, Part B, 2018
Seul Min Choi, Tae Hyun Roh, Duck Soo Lim, Sam Kacew, Hyung Sik Kim, Byung-Mu Lee
The LD50 values of BAC depend upon the species and route of administration (Table 1). Subcutaneous administration produced more potent effects in mice than rats. However, when the cream containing 0.1% (7 ml/kg) or 0.13% (5 ml/kg) BAC, respectively, was administered to Fischer 344 (F344) or Sprague-Dawley (SD) rats, adverse effects or mortality were not observed during the 2-week observation period (CTFA 1980). Bates and Edwards (2015) reported 245 cases of feline exposure to BAC. The routes of exposure were ingestion or through skin and buccal cavity. The animals were exposed to BAC contained in household antibacterial cleaners, household disinfectants, and patio cleaners. The most common signs were hypersalivation/drooling, tongue ulceration, hyperthermia, and oral ulceration.