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In Silico Approach to Cancer Therapy
Published in Anjana Pandey, Saumya Srivastava, Recent Advances in Cancer Diagnostics and Therapy, 2022
Anjana Pandey, Saumya Srivastava
The ConsensusPathDB database was established for integrating the interaction data more comprehensively. It was developed by Kamburov et al. (2009). This database has the molecular interaction networks’ integration of humans derived from various free pathway resources (http://cpdb.molgen.mpg.de). The integrated data includes diverse types of functional communications that connect diverse types of cellular entities. Presently, the database covers human functional interactions like gene regulations and physical and biochemical reactions found from the integration of 12 publicly available databases.
Evaluation of seeds ethanolic extracts of Triplaris gardneriana Wedd. using in vitro and in vivo toxicological methods
Published in Journal of Toxicology and Environmental Health, Part A, 2020
Thiago S. Almeida, Mariana R. Arantes, José J. Lopes Neto, Terezinha M. Souza, Igor P. Pessoa, Jackeline L. Medeiros, Pedro M. S. Tabosa, Thais B. Moreira, Davi F. Farias, Ana F. U. Carvalho
Toxicogenomics approaches have been used particularly to understand the mechanism of action of chemicals and generate hypothesis on which impact this would exert on human health (Wilson et al. 2013). In the present investigation, pathway analysis of the transcriptomics data using ConsensusPathDB indicated that up-regulated genes are related to drug metabolism, xenobiotic metabolism, protection against oxidative stress, and coding for heat shock. It was anticipated that exposure of exogenous compounds to the organism might induce expression of genes related to drug and xenobiotic metabolism (Xu, Li, and Kong 2005). Shintyapina et al. (2017) also identified in rats treated with phenolic compounds, increased expression of genes related to drug metabolism and xenobiotics, including those encoding for Cyp enzymes. Scapagnini et al. (2004) also reported that astrocytes exposed for 6 hr to phenolic compounds enhanced the expression of heat shock/stress proteins. Regarding the down-regulated genes, some of these are related to DNA repair, such as PARP10. A reduction or inhibition of PARP genes is associated with anti-neoplastic and anti-metastatic activity in many types of tumors (Rodríguez et al. 2013). A decrease in expression of several ID genes encoding inhibitors of DNA binding was detected. This fall is interesting because previous studies showed that in breast cancer cells there is a rise in expression of these genes, and its function is linked to cell growth (Zhou et al. 2018).