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Overview of Development of Gene Therapy
Published in Yashwant V. Pathak, Gene Delivery Systems, 2022
Ofosua Adi-Dako, Doris Kumadoh, Yashwant V. Pathak, Nana Kwame Gyamerah
Viruses in this class infect a specific type of brain cell with double-stranded DNA. Cold sores and fever blisters are caused by type 1 herpesvirus infection, which is a common human pathogen. Herpes simplex virus (HSV) is a human neurotropic virus that is mostly used in the neurological system for gene transfer (Sauderson et al., 2013). Although the wild HSV-1 virus can infect neurons and evade the host’s immune response, it can also be inactivated, resulting in a lytic cycle of viral reproduction, and as a result, a mutant HSV-1 strain that cannot replicate is commonly employed (Lundstrom, 2018).
Fatty acids and survival of bacteria in Hammam Pharaon springs, Egypt
Published in Egyptian Journal of Basic and Applied Sciences, 2018
Yehia A. Osman, Mahmud Mokhtar Gbr, Ahmed Abdelrazak, Amr M. Mowafy
The similarity in the fatty acid profile of the three local isolates was striking and convinced us to believe that the prevalent environmental condition with the Hammam had driven this similarity. It is noticeable that the dodecanoic acid (12:0) and undecanoic acid (11:0) are the predominant fatty acids in the three isolates. Moreover, they are short chain ones which fit nicely with the degree of fluidity of their membranes and survival in such environment niche. This is supported by the work of several investigators such as BROCK (1967), [18[19][20][21][22]–23] . Lauric acid or dodecanoic acid which is the most dominant fatty acids with 47.85% was found to have medical importance, especially used for treating several viral infections including (influenza; the flu); swine flu; avian flu; the common cold; fever blisters, cold sores) also Lauric acid have significant role in the treatment of genital herpes caused by herpes simplex virus (HSV), genital warts caused by human papillomavirus (HPV) and HIV/AIDS [24]. It is also used for preventing the transmission of HIV from mothers to children. Lauric acid (C12: 0), is the most potent antimicrobial saturated fatty acid [25], and have Antimicrobial Property Against Propionibacterium Acnes which consider a Therapeutic Potential for Inflammatory Acne Vulgaris [26]. Other uses for Lauric acid include treatment of bronchitis, gonorrehoae, yeast infections, Chlamydia, intestinal infections caused by a parasite called Giardia lamblia, and ringworm. Lauric acid also involved in food industry and manufacturing (soap and shampoo producing). The second prevalent and shortest fatty acid or the Capric acid (11:0) is characterized by having a good chemical stability combined with melting congruency; smaller volume change during phase transition and high latent heat of fusion per unit mass. All of these physical and chemical properties are required to suit the seasonal, which recorded at 70 °C in the winter and 90 °C in the summer.