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Role of Nanoparticles in Cancer Immunotherapy
Published in D. Sakthi Kumar, Aswathy Ravindran Girija, Bionanotechnology in Cancer, 2023
Cancer immunotherapy deploys immune cells against cancer rather than direct killing of cancer cells. Recent developments in cancer immunology provide opportunities to harness the benefit of tumor-specific immunotherapy that can eradicate the cancer cells without harming the healthy cells. Immune checkpoint blockade-based cancer immunotherapy made a paradigm shift in cancer treatment because of impressive success rate, less side effects, recurrence-free survival, and applicability to a wide range of tumors. However, a significant fraction of patients show unresponsiveness to single agent therapy for immunoinhibitory receptors. These limitations should be addressed to improve the efficacy further. Nanoparticles (NPs), owing to their special features (e.g., small size and large surface-to-volume ratio), present immense potential that can be used as adjuvant or complementation to improve the antitumor immunity.
Immunology research in Latin American countries: a bibliometric analysis of scientific productivity and collaboration covering the period 2000–2017
Published in Tapuya: Latin American Science, Technology and Society, 2021
Luis Humberto Fabila-Castillo, Ruy Fabila-Monroy, Ana Alejandra Morales-Rodríguez
To analyze the different immunological areas of research of the articles published by Latin American countries, we used the most common areas listed by most of the immunology societies (see, for example, https://www.immunology.org/public-information/what-is-immunology). They were classified in the following areas: Allergy; Autoimmunity; Basic Immunology; Cancer Immunology; Immunodeficiencies; Infectious diseases; Reproductive Immunology; Transplant immunology; Vaccines. To identify the immunological areas of the articles in the CORRAUTH consolidated files, we selected all the articles from journals whose title indicated that the journal was entirely dedicated to publishing articles in that specific immunological area. For other areas and journals, we looked for articles that had in their title words or word strings that indicated their area. For example, for infectious diseases, we used words like “brucella,” “plasmodium,” “tuberculosis,” etc. For the Immunodeficiencies area, we used the search string “immunodeficienc,” for the Transplant Immunology area, the words “transplant” or “grafts,” etc. The titles of the articles selected in this way were analyzed by one of us (LHFC) and classified in the area if the full title indicated that it matched the area. If the article could be classified in more than one area, it was classified in the area where its title indicated that it made the principal contribution. The articles that the previous strategies could not classify were analyzed one by one and classified after examining the title more closely. Articles that studied basic mechanisms of immunology were classified as Basic Immunology. For 1137 articles (14.4%), it was not possible to classify them by the criteria mentioned above.