Explore chapters and articles related to this topic
Effect of metastatic lesion size and location on the load-bearing capacity of vertebrae using an optimized ash density-modulus equation
Published in Computer Methods in Biomechanics and Biomedical Engineering, 2020
Sebastian Saldarriaga, Simon Jimenez Cataño, Asghar Rezaei, Hugo Giambini
Pathologic vertebral fractures due to metastasis can occur under normal physiologic activities (Taneichi et al. 1997). Failure of the spine’s load-bearing capacity from metastatic disease can lead to both pain and neurologic deficit (Hipp et al. 1995). Taneichi et al. (1997) determined that about 35–50% destruction of thoracic and lumbar vertebrae by a tumor would pose a clinically significant risk of collapse. On the other hand, a tumor with a volume of 24% of the whole vertebra has also been found to be a lower threshold for burst fracture (Tokuhashi et al. 2005). While lesion volume evaluations are useful, they are limited in their clinical validity as the measurement of tumor size is difficult and time-consuming (Hardisty et al. 2007).