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Artemisia and Development of Drugs from Asteraceae
Published in Debarshi Kar Mahapatra, Swati Gokul Talele, Tatiana G. Volova, A. K. Haghi, Biologically Active Natural Products, 2020
Francisco Torrens, Gloria Castellano
The STLs are a large and diverse group of secondary metabolites of many plants, mainly Asteraceae family. Given the therapeutic activity in several experimental models, STLs received attention (e.g., possess anti-inflammatory, analgesic, antitumoral, antimicrobial effects). In terms of rheumatoid arthritis (RA), mice treated with an extract of Inula helenium L., containing STLs, ameliorates collagen-induced arthritis reducing NF-κB activation and downstream cytokine production. Budlein A is an STL with antinociceptive and anti-inflammatory properties, related to the inhibition of pro-inflammatory cytokines and neutrophil recruitment. The STLs inhibit NF-κB signaling pathway and diminish inflammatory processes. They are secondary metabolites biosynthesized mainly by species from the plant family Asteraceae. They are present (e.g., lettuce Lactuca sativa, chicory Chicorium intybus L.) and represent an important part of human diet. They present anti-inflammatory, analgesic, antitumoral, antiparasitic, and antimicrobial activities.
Synthesis of Nanoparticles by Actinomycetes
Published in Mahendra Rai, Patrycja Golińska, Microbial Nanotechnology, 2020
A crucial need in the field of nanotechnology is the development of an eco-friendly and reliable process for nanoparticle synthesis. Based on available reports it can be concluded that actinomycetes have been used efficiently for nanoparticle synthesis, mainly for silver nanoparticle synthesis, by means of a low-cost, natural and renewable bio-reducing agent. Optimization of the culture conditions for actinomycetes made it possible to obtain small and stable nanoparticles. Actinomycete-mediated silver nanoparticles showed good antibacterial, antifungal, antibiofilm, antiparasitic and anticancer activities. Thus, activities of AgNPs from actinomycetes indicate their potential application in the field of nanomedicine.
Metabolic Engineering for the Production of a Variety of Biofuels and Biochemicals
Published in Kazuyuki Shimizu, Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production, 2017
Polyketides are used as antibiotic, immunosuppressant, antitumor, antifungal and antiparasitic agents. All polyketides are assembled by successive round of decarboxylative condensation between an acyl thioester and a-carboxythioester in a similar way as fatty acid synthesis (Yuzawa et al. 2011). Polyketides are commonly produced from the precursors such as malonyl-CoA and (2S)-methylmalonyl-CoA, where E. coli produces only the former metabolite at the sufficient level to promote polyketide synthesis, and thus some metabolic engineering strategy is required to generate (2S)- methylmalonyl-CoA (Yuzawa et al. 2011).
The Lantana camara L. stem biomass as an inexpensive and efficient biosorbent for the adsorptive removal of malachite green from aquatic environments: kinetics, equilibrium and thermodynamic studies
Published in International Journal of Phytoremediation, 2023
Mohsen Samimi, Mohsen Shahriari-Moghadam
Malachite green (MG) is a cationic dye commonly used to dye leather, wool, silk, hemp, nylon, linen, etc. (Ahmad Khan et al. 2023). This triphenylmethane dye is used as an antifungal, antibacterial and antiparasitic compound in aquaculture. The strong antibacterial properties of MG are related to its operation in inhibiting intracellular enzymes and counteracting DNA and cell membranes, thus having carcinogenic, cytotoxic effects and damage to skin and eyes, etc. (Chen et al. 2014; Guechi and Hamdaoui 2016). For the removal of dyes from water and wastewater, a variety of physical, chemical, and biological methods have been used, including photocatalytic degradation (Zhang et al. 2010), removal by microorganisms (Khataee et al. 2013), use of activated carbon (Zhang et al. 2016), hydrogels (Samimi and Moeini 2020), Metal-organic framework (Samimi and Safari 2022) and various sorbents (El Hassani et al. 2017).
Synthesis, characterization, photoluminescence properties, DFT studies, photocatalytic and antifungal activity of a new pyrazole-containing thiosemicarbazone ligand and its Co(III) and Ni(II) complexes
Published in Journal of Coordination Chemistry, 2023
Manan Saha, Suman Mandal, Ankika Bhakat, Keka Sarkar, Asoke Prasun Chattopadhyay, Nitis Chandra Saha
Thiosemicarbazones (TSCs) can be referred to as a multi-talented class of Schiff base ligands, which often display various binding modes with metals [1]. They generally attach to a metal ion in neutral or anionic form as they exhibit thione–thiol tautomerism [2]. Thiosemicarbazones show strong coordinating capability towards metal ions [3–5]. The varied biological activities of several heterocyclic thiosemicarbazones are often credited to their chelation capacity towards transition metal ions [6]. TSCs have emerged as an important class of molecules resulting in a library of compounds with well-established medicinal and pharmacological properties such as antifungal, antiviral, antimicrobial, antitumor, bactericidal, anti-inflammatory, antiparasitic and anti-tuberculosis activities [7–16]. Furthermore, thiosemicarbazones exhibit activities against microbial diseases such as malaria, small-pox, influenza, leishmaniasis [17–22], neurological pathologies [23, 24] and cancer [25–35].
First report on the production of phytotoxic metabolites by Mycoleptodiscus indicus under optimized conditions of submerged fermentation
Published in Environmental Technology, 2022
Valéria Ortaça Portela, Anderson Moro, Natielo Almeida Santana, Daiana Bortoluzzi Baldoni, Isac Aires de Castro, Zaida Inês Antoniolli, Ionara Irion Dalcol, Rodrigo Josemar Seminoti Jacques
M. indicus belongs to the phylum Ascomycota, class Dothideomycetes, order Muyocopronales, and family Muyocopronaceae [35]. M. indicus is difficult to identify due to its morphological characteristics; therefore, we identified it using molecular methods. The most relevant morphological structures are the presence of appressoria, dark phialides, conidiogenic cells with prominences and aggregates within the sporodoquial mass, and hyaline and hyaline conidia [36–38]. M. indicus produces sporodochia and not sclerotia, as do M. terrestris and M. sphericus [36–38]. M. indicus is considered endophytic, and occurs mainly, but not exclusively, in monocotyledonous leaves. It has been isolated from the leaf lesions of Zamia spp., a genus that comprises about 40 plant species, with a broad geographical distribution [37,39]. In a study conducted in the State of Pernambuco in Brazil, five specimens of M. indicus were isolated from the samples of the plant Borreria verticillata (L.) GFW Meyer, which is native to South America. Its metabolites displayed antimicrobial, antiparasitic, and antitumor activities, and belong to the chromene and azaphilone classes [38]. Azaphilones exhibit a broad spectrum of biological action, such as antimicrobial, antifungal, antioxidant, antiviral, cytotoxic, and nematicide activity [40], demonstrating the importance of this fungus in other biotechnological applications.