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Cancer/Anti-Cancer Chemotherapy: Pharmacological Management
Published in Mihai V. Putz, New Frontiers in Nanochemistry, 2020
Bogdan Bumbăcilă, Corina Duda-Seiman, Daniel Duda-Seiman, Mihai V. Putz
Antimetabolites are interfering with DNA synthesis; therefore, cell division and cellular growth and because cancer cells have a dividing potency higher than normal cells, the cancer tissues’ growth is affected more.
Preparation of α-Tocopherol based nanoemulsion for efficacious delivery of Methotrexate
Published in Journal of Dispersion Science and Technology, 2023
Jyoti Rathee, Rohini Kanwar, Laxmi Kumari, Sandip V. Pawar, Deepak B. Salunke, Surinder Kumar Mehta
Methotrexate (MTX), a folate antimetabolite drug, is commonly employed for cancer treatment. The conventional therapy of MTX is challenged by multiple drug resistance properties that hinder its therapeutic efficiency.[7] The clinical efficiency of the MTX is compromised by its low bioavailability, short half-life span, and its side effects. Rajitha and coworkers[8] prepared MTX loaded chaulmoogra oil-based NEm of 34.52 ± 2.05 nm size by emulsification technique and ex-vivo skin permeation studies were performed by employing porcine skin. The results showed the enhanced skin permeation and retention of drugs in the deep skin layers in comparison to the control drug solution. The developed NEm formulation was found to be cytocompatible toward the L929 cell line and was stable for 3 months. However, MTX release from chaulmoogra oil-based NEm was slow and in a controlled manner, but it was not a sustained release. NEm system can itself behave as an antioxidant agent and might display symbiotic action with other anticancerous molecules utilized in drug delivery. Therefore, the development of a better formulation that offers higher solubility, increased bioavailability, and sustained release of anticancer drugs stays in demand in the era of nanomedicine research.