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Cancer/Anti-Cancer Chemotherapy: Pharmacological Management
Published in Mihai V. Putz, New Frontiers in Nanochemistry, 2020
Bogdan Bumbăcilă, Corina Duda-Seiman, Daniel Duda-Seiman, Mihai V. Putz
They are also called antifolates because they block the effects of folic acid (vitamin B9). Folic acid’s primary action in the organism is to function as a cofactor for methyltransferase enzymes involved in thymidine, purine, and sulfur-containing amino acids synthesis. The majority of antifolates inhibit these enzymes when they participate as mischievous cofactors (as they have resemblances in their chemical structures with the one of folic acid). Therefore they stop the cell division, nucleic acids synthesis, and repair and protein synthesis (Takimoto, 1996). Some of the molecules in this class can selectively inhibit folate’s actions in microbial organisms and not in the human organism that is parasitized by these (Gangjee et al., 2007). For example, trimetrexate can be given to AIDS suffering patients with Pneumocystis carinii infection (Allegra et al., 1987).
Engineering of 177Lu-labeled gold encapsulated into dendrimeric nanomaterials for the treatment of lung cancer
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Zheng Wang, Minhua Ye, Dehua Ma, Jianfei Shen, Fang Fang
Bombesin and GRP-similar peptides have been implicated as growth factors in various kinds of carcinoma over the last two decades. Most of the lung cancer tissues overexpress the gastrin-releasing peptide receptors [41–44]. Several bombesin derivatives with solid potential for GRPR have explored in clinical investigations for specific receptors treatment and imaging. Radionuclide imaging of lung cancers has been successfully performed using radio-bombesin analogues in clinical trials [45–47]. Therefore, HEL-299 human lung cells have been utilized as tumour models to assess novel bombesin probes [48]. A membrane-bound protein with a great affinity for binding and delivering folate into cells, folate receptor-α (FR-α) is a folate receptor. Enhanced control of cell metabolism, folate is also involved in DNA synthesis and repair and cellular respiration. Antifolates are often used in cancer treatment because cancer cells, which quickly increase, have higher folate requirements to retain DNA engineering. All lung cancer subtypes and overexpress FRs. FRs are significantly expressed in HEL-299 cells, according to current polymerase chain reaction (PCR) investigations [49–52].