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Anti-Inflammatory, Antimicrobial and Other Beneficial Effects of Allium sativum (Garlic)
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Moreover, ajoene was also identified to counteract the activity of COX2 and the secretion of prostaglandin E2. One of the organosulfur constituents of garlic, diallyl trisulfide, has prospective anti-inflammatory activity, and it works by decreasing the cytokines and arbitrates in in vivo and in vitro experiments (Walag et al., 2020). Furthermore, this constituent also demonstrated the capacity of inhibiting LPS (lipopolysaccharide)-prompted foot oedema in rat models. Sulforaphane was also established to be beneficial as a healing agent for managing inflammation-associated disorders (Chen et al., 2009).
Ameliorating Insulin Signalling Pathway by Phytotherapy
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Ethnopharmacology of Wild Plants, 2021
A bulbous plant growing up to 1 m high is popular globally by its pungent flavour as a seasoning or condiment used in spice. A. sativum is famous for its English name garlic belonging to the family Amaryllidaceae. The plant consists of a bulb growing to 25–70 cm with bisexual flowers. The species is originally from Asia but is cultivated almost all over the world like China, North Africa (Egypt), Europe and Mexico (Mikaili et al. 2013). Studies were carried out to analyse the chemical composition and found that sulphur compounds such as allicin, alliin are major constituents along with diallyl disulphide (DDS), S-allylcysteine (SAC) and diallyl trisulfide (DTS), (E)-ajoene and other organosulphides as minor components which play crucial pharmacological roles (Lanzotti et al. 2012). Some of the pharmacologically active constituents are shown in Figure 15.3.
Anti-Inflammatory Properties of Bioactive Compounds from Medicinal Plants
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Health Benefits of Secondary Phytocompounds from Plant and Marine Sources, 2021
Muhammad Imran, Abdur Rauf, Anees Ahmed Khalil, Saud Bawazeer, Seema Patel, Zafar Ali Shah
Naphthalene-induced oxidative injury is inhibited by diallyl trisulfide (DATS: an organosulfur compound), which is responsible for the inflammatory response in vitro in A549 cells. DATS application in low dose groups has shown good free radical scavenging potential mainly due to enhanced activities of SOD. Studies revealing the mechanism of action for DATS-mediated inhibition in induced oxidative injuries and formation of pro-inflammatory responses (IL-8, TNF-α, and IL-6) were ascribed to inhibition of NF-κB [56]. SAC (S-allyl cysteine) is another promising organosulfur compound present in garlic possessing anti-inflammatory and redox modulating potentials, along with pro-energetic and anti-apoptotic activities [24].
Hydrogen sulfide: a target to modulate oxidative stress and neuroplasticity for the treatment of pathological anxiety
Published in Expert Review of Neurotherapeutics, 2020
Mary Chen, Caroline Pritchard, Diandra Fortune, Priyadurga Kodi, Marco Grados
The use of natural sulfide-releasing compounds has gained recent attention given the rapid absorption of natural foods and the low toxicity involved. Garlic (allium sativum) has over 100 bioactive compounds, including S-allylcysteine, saponins, ajoene, flavonoids, and phenolics, several of which are antioxidants [116]. Allicin, an extremely unstable and odorless product of garlic, rapidly breaks down into organic diallyl polysulfides diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), as well as ajoene [114]. Garlic homogenates contain many other S-harboring compounds such as allyl methyl thiosulfonate, 1-propenyl allyl thiosulfonate and -L-glutamyl-S-alkyl-L-cysteine, among others [117], but the greatest efficacy in releasing H2S from these molecules may rest mostly on DATS [118]. The H2S-releasing activity of garlic can thus be measured as diallyl trisulfide equivalents (DATS-E), and is highest when garlic is boiled from 6 to 10 mins, but not longer [119].
Diallyl Trisulfide Suppresses the Renal Cancer Stem-like Cell Properties via Nanog
Published in Nutrition and Cancer, 2023
Taotao Zhang, Wanshuang Cao, Hongliang Sun, Dexin Yu, Caiyun Zhong
Garlic-derived organosulfur compound diallyl trisulfide (DATS) has been shown to exhibit multiple bioactive properties, such as antioxidation, anti-inflammation and anticancer. Several In Vivo studies demonstrated that DATS had anticancer activity in different cancers, such as prostate cancer, melanoma, breast cancer and gastric cancer (12–15). Zhang et al. reported that DATS suppressed colorectal CSCs via the inhibition of Wnt/b-catenin activation (16). However, the effects of DATS on stem-like renal cancer cells, as well as the corresponding underlying molecular mechanism remain largely unclear.
The potential agents from food for preventing leukopenia induced by benzene: garlic preparations
Published in Toxicology Mechanisms and Methods, 2019
Wenting Han, Ruogu Liu, Xiaoshuai Zhang, Peng Lv, Ming Li, Xujing Wang
Garlic homogenate was freshly prepared before gavage every day. Garlic oil was purchased from Xuchang Yuanhua Biotechnology CO., Ltd (Xuchang, Henan, China). The contents of diallyl disulfide (DADS) and diallyl trisulfide (DATS), 2 major biological components of GO, were 31.1% and 49.3%, respectively. DATS (purity > 97%) was purchased from Jiang Su Chiatai Qingjiang Pharmaceutical Co., Ltd.(Jiangsu, China).