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The Effects of Pharmaceuticals, Environmental, and Occupational Agents on Sperm Motility
Published in Claude Gagnon, Controls of Sperm Motility, 2020
Kallikrein therapy is empirically based and so far very few parameters are available to predict for an individual patient whether such therapy will be successful. However, a study by Berzin et al.119 showed an association between ATP consumption and sperm motility in kallikrein-treated patients. ATP levels were higher in patients responding to kallikrein as compared to nonresponders. In addition, Saitoh et al.120 have shown that kallikrein levels increased in semen with a parallel decrease in sperm density. However, there was no correlation between kallikrein levels and sperm motility. Indeed, in some men with poly-zoospermia, normalization of sperm numbers have been found. It appears that optimal results are obtained in idiopathic forms of oligozoospermia and asthenozoospermia, but not in spermatogenic arrest or severe testicular failure.121,120
Psychological Impact of Infertility and Assisted Reproduction 1
Published in Rosa Maria Quatraro, Pietro Grussu, Handbook of Perinatal Clinical Psychology, 2020
Fertility disorder diagnoses are distributed more or less equally across women and men. In approximately 40% of cases, both partners have fertility disorders, in about a third of them the cause is associated exclusively with the woman partner, in about a fifth of them exclusively with the man, and in fewer than 10% no cause of infertility can be detected in either partner (Wischmann, 2012). Chief among the causes of infertility in women are ovulation disorders in about one-third of all cases, damage to the fallopian tubes in about a quarter of such instances, and – more rarely – endometriosis or cervical factors. In men, the OAT syndrome is the most frequent culprit (impaired sperm concentration, motility, morphology) followed by asthenozoospermia (sperm motility defect) and teratozoospermia (abnormal sperm morphology).
mTOR signaling in spermatogenesis and male infertility
Published in Rajender Singh, Molecular Signaling in Spermatogenesis and Male Infertility, 2019
The role of the mTOR pathway in male reproductive function emerged when several clinical reports suggested that treatment with mTOR inhibitor sirolimus (also known as Rapamycin) is related to changes in sex hormone levels (lower testosterone, increased levels of luteinizing and follicle-stimulating hormones LH and FSH) and male infertility (37). Further studies also reported low sperm count (oligozoospermia), decreased sperm motility (asthenozoospermia), loss of sperm vitality and reduced percentage of normal sperm (38). A case study reporting sirolimus-associated infertility in a young male after heart-lung transplant provided the potential mechanism of sirolimus effects on spermatogenesis through mTOR and p70S6 kinase-mediated signaling pathways causing sexual hormone dysfunction, seminiferous tubule dystrophy and spermatogenesis blockade (39). Fortunately, the cessation of sirolimus treatment showed complete normalization of the sex hormones and sperm quality parameters (38–40).
Qiangjing tablets ameliorate asthenozoospermia via mitochondrial ubiquitination and mitophagy mediated by LKB1/AMPK/ULK1 signaling
Published in Pharmaceutical Biology, 2023
Guangsen Li, Yuanjie Xu, Yingxi Li, Degui Chang, Peihai Zhang, Ziyang Ma, Di’ang Chen, Yaodong You, Xiaopeng Huang, Jian Cai
Infertility is a common reproductive disorder with increasing morbidity that affects many couples worldwide (Moore and Reijo-Pera 2000; Vander Borght and Wyns 2018). Male infertility, which mainly manifests as abnormalities in sperm concentration, motility, and morphology, accounts for approximately half of all infertility cases (Hwang et al. 2011). Asthenozoospermia (AZS), characterized by low sperm motility (progressive and non-progressive sperm motility <40%, or progressive sperm motility <32%), has been demonstrated to contribute to 40% of male infertility (Liu et al. 2015). The occurrence of AZS involves numerous factors, such as chromosome malformation, perturbed gene modulation, endocrine imbalance, and factors related to infection, immunity, and the environment (Balkan et al. 2008). Microsurgery and auxiliary reproductive technology are the main therapeutic approaches for treating male infertility (Agostini et al. 2017; Punjani et al. 2021). Various types of drugs are used to treat male infertility, but their therapeutic effects remain suboptimal (Chehab et al. 2015). Thus, developing effective drugs to treat AZS and male infertility is necessary.
CCDC9 is identified as a novel candidate gene of severe asthenozoospermia
Published in Systems Biology in Reproductive Medicine, 2019
Yanwei Sha, Yankai Xu, Xiaoli Wei, Wensheng Liu, Libin Mei, Shaobin Lin, Zhiyong Ji, Xu Wang, Zhiying Su, Pingping Qiu, Jing Chen, Xiong Wang
The proband (32 years of age, Figure 1A, II:3) and his family were recruited for this research from the Affiliated Yantai Yuhuangding Hospital of Qingdao University. The proband had sex 2–3 times per week with normal erection and ejaculation in the past five years after marriage, but his wife did not conceive. The patient has an elder brother (Figure 1A, II:2) who has a daughter (Figure 1A, III:1). The patient exhibited normal secondary sexual characteristics and physical examination results were as follows: height, 175 cm; weight, 73 kg; external genital development, normal; bilateral testicular size, normal; and bilateral spermatic vein, normal. The semen examination results from our hospital were as follows: semen volume, 2.5 mL; semen pH, 7.5; sperm density, 20.5 million/mL; percentage of progressive motility, 0%; percentage of non-progressive motility, 1%; and percentage of immotile sperm, 99%. Sperm morphology showed a normal morphology of 3.4%. Seminal plasma biochemical testing indicated that fructose level, neutral glycosidase activity, and seminal plasma zinc level were normal. The reproductive hormones were within normal ranges (FSH 2.36 mIU/mI, LH 1.85 mIU/ml, T 3.76 ng/ml, E2 24 pg/ml, PRL 7.33 ng/ml). The chromosomal karyotypes of the patient were normal, 46, XY and no microdeletion was found in the Y chromosome. Based on these results, the patient was diagnosed with severe asthenozoospermia.
Telomeres as a molecular marker of male infertility
Published in Human Fertility, 2019
Ewa Boniewska-Bernacka, Anna Pańczyszyn, Natalia Cybulska
Infertility is a disease of couples, meaning that there is no possibility of conceiving a child by natural conception for a duration of at least 12 months (Cooper et al., 2010; Jungwirth et al., 2015; Zegers-Hochschild et al., 2009). Infertility currently affects ∼15% of couples (Jungwirth et al., 2015). The proportion of male factor involvement accounts for as much as 51% of infertility issues (Agarwal & Said, 2003; Jungwirth et al., 2015) and the probability of conception depends on semen quality. Assessing male fertility involves a preliminary assessment that is based primarily on semen analysis (Practice Committee of the American Society for Reproductive Medicine, 2015). Reduced sperm concentration (oligozoospermia) and motility (asthenozoospermia), the percentage of morphologically normal sperm (teratozoospermia) and total absence of sperm in the ejaculate (azoospermia) are considered the main causes of male infertility (World Health Organization, 2010).