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Male Sexual Dysfunction and Male Factor Infertility
Published in Karl H. Pang, Nadir I. Osman, James W.F. Catto, Christopher R. Chapple, Basic Urological Sciences, 2021
Asthenospermia: reduced progressive sperm motility (<32%).WHO (1999) classification of motility:Rapid progressive, slowly progressive, non-progressive, non-motile
Male infertility
Published in C. Yan Cheng, Spermatogenesis, 2018
Ryan Flannigan, Marc Goldstein
Eight percent of men presenting with infertility will have a sperm concentration less than 15 million/mL and be classified as asthenospermia.22 The minimal number of sperm to achieve a natural pregnancy is unknown. Several studies have evaluated the effect of sperm concentration and time to pregnancy. Results suggest that an increased trend is observed among sperm concentrations increasing to 40–55 million/mL, but the effect levels out at greater concentrations.23,24 Thus, low sperm concentrations below 40 million/mL may have an impact on time to natural pregnancy among couples. With respect to IUI, sperm concentration and total motile count (motility × total sperm count) have been demonstrated to be the strongest predictors of success. Total motile count of 5 million or greater portends to greater IUI pregnancy rates.25 IVF results are best with 3 million total motile count.26
Fertility issues in men with spinal cord injury
Published in Jacques Corcos, David Ginsberg, Gilles Karsenty, Textbook of the Neurogenic Bladder, 2015
Jeanne Perrin, Blandine Courbiere, Vincent Achard, Catherine Metzler-Guillemain
Brackett et al.22 showed that in SCI patients, motility and viability of sperm extracted from vas deferens are statistically higher than those observed in sperm from seminal fluid. Motility and viability of SCI patients’ epididymal sperm are also statistically lower than in epididymal sperm of control group (non-SCI men receiving vasectomy). Two studies also demonstrated that the incubation of control sperm (from fertile men or donors) in the seminal fluid of SCI patients induced a major decrease in sperm motility, when the incubation of SCI patients’ sperm in control seminal fluid increased sperm motility.23,24 These results suggested that some testicular/epididymal and seminal factors may account for asthenospermia in chronic SCI patients.
CCDC9 is identified as a novel candidate gene of severe asthenozoospermia
Published in Systems Biology in Reproductive Medicine, 2019
Yanwei Sha, Yankai Xu, Xiaoli Wei, Wensheng Liu, Libin Mei, Shaobin Lin, Zhiyong Ji, Xu Wang, Zhiying Su, Pingping Qiu, Jing Chen, Xiong Wang
Asthenozoospermia (AZS), also known as asthenospermia, is the most common cause of infertility worldwide and can be detected in up to 40% of infertile male patients (Dirami et al. 2013; Xu et al. 2018). Owing to less than 1% motile spermatozoa in the ejaculated semen, severe asthenozoospermia is a serious challenge in reproductive medicine (Marchini et al. 1991). Severe asthenozoospermia has a complex etiology that includes metabolic defects (Wilton et al. 1992), flagella abnormalities (Collodel et al. 2011; Moretti et al. 2011), genital tract infections (Lores et al. 2018), varicocele (Amer et al. 2015; Mostafa et al. 2016, 2018), unhealthy lifestyle, antisperm antibodies (ASA) (Harrison 1978; Marchini et al. 1991; Dimitrov et al. 1994; Shibahara et al. 2005), and necrozoospermia (Gopalkrishnan et al. 1995). Unfortunately, due to its complex etiology, the exact pathogenesis of severe asthenozoospermia remains largely unclear for a majority of the patients.
The association between trans fatty acids, infertility and fetal life: a review
Published in Human Fertility, 2019
Hande Çekici, Yasemin Akdevelioğlu
A possible effect of TFAs on diminished sperm count may be in terms of a decrease in the activity of Δ5 and Δ6-desaturases which affect spermatogenesis, potentially restricting the integration of long-chain PUFAs into sperm membranes (Chavarro et al., 2014). The association between asthenospermia, which is defined as decreased sperm motility, and nutrition is still unknown. The correlation between TFAs and asthenospermia is especially striking. Thus, in a current case control study on men with asthenospermia; evaluation of dietary intake, semen quality and endocrinological parameters has shown that TFAs, palmitic acid and stearic acid have a positive relationship with asthenospermia (Eslamian et al., 2015). Conversely, high levels of n–3 fatty acid and DHA intake has been linked to lower rates of asthenospermia. Consequently, findings from various studies suggest that TFA intake increases the risk of asthenospermia (Eslamian, Amirjannati, Rashidkhani, & Sadeghi, 2012; Eslamian et al., 2015). Similarly, a controlled study on 107 male patients with asthenospermia aged between 20 and 40 years has revealed that a western-style diet not only had a positive correlation with asthenospermia, but that constituted an undesirable risk factor.
Prediction of male infertility by the World Health Organization laboratory manual for assessment of semen analysis: A systematic review
Published in Arab Journal of Urology, 2018
Amir S. Patel, Joon Yau Leong, Ranjith Ramasamy
A semen analysis is only a gross estimation of fertility but it is, unfortunately, the best test we have. Semen analysis can predict fertility in men with azoospermia, severe asthenospermia and globozoospermia. In other cases, semen analyses have a limited role in the evaluation of infertility because female factors can influence fecundity in most couples. It is important to realise that all men who were included in the WHO fifth edition were fertile. Lower reference limit threshold points for semen parameters at the 5th percentile should be used as a reference for counselling couples and not be used to label men as ‘fertile’ or ‘infertile’.