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Biology and Distribution of Venomous Snakes of Medical Importance and The Composition of Snake Venoms
Published in Jürg Meier, Julian White, Handbook of: Clinical Toxicology of Animal Venoms and Poisons, 2017
All basic low-molecular weight myotoxins known to date were isolated from venoms of the rattlesnake genus Crotalus (Table 3). The precise mode of action of the small myotoxins is not yet elucidated. However, it has been shown that crotamine62 and myotoxin a63 lead to a permeability increase of the sodium channel or its modulator for sodium ions.
Crotamiton
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Crotamiton is available for topical use only as a cream or lotion. It is used for the treatment of scabies caused by the mite Sarcoptes scabiei, for other mite infestations, for head and pubic lice infestations, and for the symptomatic treatment of pruritus. Formulations available on the market usually contain 10% crotamiton. It was first commercialized by Geigy, and marketed for the treatment of scabies in 1946 (Burckhardt and Rymarowicz, 1946; Domenjoz, 1946; Roos et al., 2001). Crotamiton has been confused with crotamine, a myotoxin from the venom of the South American rattlesnake Crotalus durissus terrificus.
Crotamine-like from Southern Pacific rattlesnake (Crotalus oreganus helleri) Venom acts on human leukemia (K-562) cell lines and produces ultrastructural changes on mice adrenal gland
Published in Ultrastructural Pathology, 2018
Elda E. Sánchez, Roschman González, Sara Lucena, Stefanie García, Héctor J. Finol, Montamas Suntravat, María E. Girón, Irma Fernández, Alexis Rodríguez-Acosta
Crotamine, one of the important Crotalus venom constituents has caught significant consideration, because its high utility in neuroscience research, drug progressing, and molecular diversity reports. Crotamine is a cationic, non-enzymatic, protein integrating to a minor family of myotoxins composed of 42 amino acid residues, which contains 6 cysteine that form three disulfide bonds making up a tightly wound β-sheet core,4 found principally amid the Viperidae and Crotalidae families of snakes.
Recent advances and future perspectives in the pharmacological treatment of Candida auris infections
Published in Expert Review of Clinical Pharmacology, 2021
Daniele R. Giacobbe, Laura Magnasco, Chiara Sepulcri, Malgorzata Mikulska, Philipp Koehler, Oliver A. Cornely, Matteo Bassetti
Crotamine is a myotoxin from the venom of the South American rattlesnake Crotalus durissus terrificus structurally similar to human AMPs β-defensins, with cytotoxic and neurotoxic functions, showing anti-C. auris activity in vitro that may rely on the interaction with the lipid bilayer of the cell wall and dysregulation of ion channels [95].