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Group B Streptococcus
Published in Vincenzo Berghella, Maternal-Fetal Evidence Based Guidelines, 2022
Newborns of patients undergoing cesarean delivery before labor or ROM have an extremely low risk for early onset GBS disease. Antibiotic prophylaxis is not recommended in this circumstance. However, patients planning to be delivered by cesarean should still undergo screening for GBS, in case they present in labor or with ROM.
Uterine Artery Embolization
Published in John C. Petrozza, Uterine Fibroids, 2020
Gloria M. Salazar, Eric Paul Wehrenberg-Klee
Some institutions initiate patients on calcium channel blockers such as nifedipine to reduce the risk of uterine artery vasospasm secondary to catheter manipulation during the procedure. On the day of the procedure, after routine periprocedural evaluation, the patient may receive a diclofenac suppository to assist with pain control, with use varying across institutions. Antibiotic prophylaxis use across institutions also varies. Placement of a Foley catheter is standard, as the patient may have to lie flat for several hours after the procedure, depending on the arteriotomy site and whether or not a closure device is used.
Knowledge Area 4: Post-operative Care
Published in Rekha Wuntakal, Ziena Abdullah, Tony Hollingworth, Get Through MRCOG Part 1, 2020
Rekha Wuntakal, Ziena Abdullah, Tony Hollingworth
When preforming an instrumental delivery, antibiotics are not required. All other procedures require antibiotics.Further readingScottish Intercollegiate Guidelines Network. Antibiotic Prophylaxis in Surgery. SIGN Guideline 104. Edinburgh, Scotland: SIGN, 2014.National Institute for Health and Clinical Excellence. Routine Preoperative Tests for Elective Surgery. NG45. London, UK: NICE, 2016.
A glimpse into relapsed refractory multiple myeloma treatment in real-world practice in Spain: the GeminiS study
Published in Hematology, 2023
Rafael Ríos-Tamayo, Juan Alfons Soler, Ricarda García-Sánchez, Ernesto Pérez Persona, Mario Arnao, Antoni García-Guiñón, Abel Domingo, Miriam González-Pardo, Javier de la Rubia, María Victoria Mateos
The toxicity observed in our study seems to be underestimated. This value is lower than that reported in RCTs [11,24,28,44] for the two study groups. This difference may be due to the observational nature of this study as well as the difficulty of conducting this type of study in RW practice. Regarding the standard of care regimens evaluated in the study (Group A), a plausible explanation may also be derived from their greater experience of use and their consequent lower reporting frequency. Regarding the tolerability of the study daratumumab combinations (Group B), the adverse event profile was actually as expected and consistent with previously reported studies [24,28]. Interestingly, although one of the most commonly observed adverse events was infections, the reported use of antimicrobial prophylaxis was low, suggesting that a wider use of antibiotic prophylaxis could have prevented or attenuated the occurrence of those complications.
Conventional and emerging treatments and controversies in myasthenia gravis
Published in Expert Review of Neurotherapeutics, 2023
Amelia Evoli, Valentina Damato
Susceptibility to meningococcal infections is the main concern in patients treated with terminal complement inhibitors. Complement bactericidal activity through MAC formation is required for protections against Neisseria species and vaccination does not eliminate the risk of infection [114]. Eculizumab and ravulizumab are approved for treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. A 10-year safety analysis, in eculizumab-treated patients confirmed the increased risk of meningococcal disease, together with infections from Neisseria species other that Neisseria meningitidis and other bacterial infections. Patient monitoring, prompt diagnosis and treatment and, when appropriate, antibiotic prophylaxis are recommended for risk mitigation [115].
Infections and Colon Surgery: Preliminary Results from a Surveillance Program in an Italian Hospital
Published in Hospital Topics, 2023
Giancarlo Ripabelli, Angelo Salzo, Michela Lucia Sammarco, Giuliana Guerrizio, Giuseppe Cecere, Manuela Tamburro
Antibiotic prophylaxis is useful to prevent antimicrobials overuse, misuse and abuse, as well as helpful to reduce SSIs incidence, and minimize effects on the patient’s bacterial flora and changes to the immune defenses (Murri et al. 2016). Indeed, perioperative prophylaxis must be carried out with the right antibiotic, dose and timing, based on the classification of the intervention, in line with the most recent guidelines for the control of HCAIs, and taking into account the occurrence of bacterial resistance (Crader and Varacallo 2020; Napolitano et al. 2013). Although the causative pathogens of SSIs depend on the type of surgery, Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus spp. and Escherichia coli represent the microorganisms most frequently isolated (Owens and Stoessel 2008; Weigelt et al. 2010; Eisner et al. 2020).