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Psychotropic Use during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Methaqualone (Quaalude, Sopor, Parest) is an effective hypnotic and sedative agent and is not presently commercially available. No clear medicinal advantage of methaqualone over the other available hypnotics can be shown and the drug is commonly abused by drug-dependent people. Tolerance to the drug develops in abusers. No published reports are available that analyze the possible association of the use of methaqualone during pregnancy with congenital malformations. However, its use during gestation is not recommended because of its abuse potential. The frequency of congenital anomalies was not increased among rats or rabbits whose mothers were administered 200 mg/kg methaqualone orally (rabbits) from days 1 to 29 or 100 mg/kg (rats) from days 1 to 20 (Bough et al., 1963).
Soranus. Caelius Aurelianus and His “ De Morbis Acutis Et Chronicis Libri VIII
Published in Charles Greene Cumston, An Introduction to the History of Medicine, 2018
Caelius insists upon the intense constriction of the pores as Asclepiades had taught, and remarks that it is this intensity that makes the difference between disease and the slight constriction that may occasionally be observed in the healthy state. According to the Methodists, this very great change arising in the pores produces fever by disturbing the entire body. According to Asclepiades, constriction of the pores produced sopor, and it was thus that he explained the somniferous action of poppy. The symptoms of phrensy, as described by various writers of the Methodist sect, are as follows. In the first place there were the premonitory phenomena according to Asclepiades and the majority of the physicians of the other sects, but these hardly fitted in with the system of the Methodists, so that Thessalus and his disciples denied their existence, saying that in this so-called premonitory phase the disease was already constituted. Neither did they believe that phrensy only occurred at certain determined periods of the year, for example, in autumn.
Real-world use of the sufentanil sublingual tablet system for patient-controlled management of acute postoperative pain: a prospective noninterventional study
Published in Current Medical Research and Opinion, 2020
Esther Pogatzki-Zahn, Peter Kranke, Judit Winner, Wolfgang Weyland, Alexander Reich, Ursula Vigelius-Rauch, Michael Paland, Thorsten Löhr, Leopold Eberhart
The intensity of 30 (30.6%) ADRs was reported as mild, 40 (40.8%) as moderate, and 8 (8.2%) as severe (including the 7 serious ADRs). The 7 serious ADRs occurred in 2 patients. Bradycardia and cardiac arrest occurred in 1 patient, however, the instance of cardiac arrest was judged to be unlikely related to sufentanil administration. In the second patient, recorded serious ADRs were: toxicity to various agents, oxygen desaturation, low respiratory rate, sopor, and respiratory failure. Causality of toxicity to various agents was determined to be unassessable/unclassifiable to sufentanil therapy, and respiratory failure was judged to be unlikely related to sufentanil administration. No fatalities occurred.
Post-marketing and clinical safety experience with sodium oxybate for the treatment of alcohol withdrawal syndrome and maintenance of abstinence in alcohol-dependent subjects
Published in Expert Opinion on Drug Safety, 2020
Giovanni Addolorato, Otto-Michael Lesch, Icro Maremmani, Henriette Walter, Felice Nava, Quentin Raffaillac, Fabio Caputo
The pharmacovigilance database for Alcover® (Alcover syrup, D&A Pharma, Austria and Alcover-17.5% oral solution, Laboratorio Farmaceutico C.T, Italy) included 299 013 patients who were exposed to SMO for the treatment of AWS (about 73% of treated patients) and for the long-term treatment of alcohol dependence (about 27% of treated patients) [4,72,73]. Common, non-serious adverse events (AEs) were reported in 17 patients (0.3%; mainly vertigo, nausea and diarrhea) in Austria and 68 patients (0.02%; mainly vertigo, nausea and sopor) in Italy. No fatal AE was reported in these pharmacovigilance databases.