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Overview of Traditional Methods of Diagnosis and Treatment for Women-Associated Cancers
Published in Shazia Rashid, Ankur Saxena, Sabia Rashid, Latest Advances in Diagnosis and Treatment of Women-Associated Cancers, 2022
Malika Ranjan, Namyaa Kumar, Safiya Arfi, Shazia Rashid
The surgical procedures used for ovarian cancer include unilateral and bilateral salpingo-oophorectomy and debulking or cytoreduction [19]. The most common surgery used for endometrial cancer is a total hysterectomy. Vulvectomy and vaginectomy are the surgical procedure used for treating vulvar and vaginal cancer, respectively.
Malignant and premalignant conditions affecting the genital area
Published in Shiv Shanker Pareek, The Pictorial Atlas of Common Genito-Urinary Medicine, 2018
Surgical removal of affected tissue is the treatment of choice: Vulvectomy – removal of vulva tissue.Surgical removal of inguinal and femoral lymph nodes.Chemotherapy or radiation therapy – in advanced cases.
Vulvar lichen sclerosus
Published in Miranda A. Farage, Howard I. Maibach, The Vulva, 2017
Jill M. Krapf, Andrew T. Goldstein
Historically, vulvectomy was considered to be an acceptable surgical option for vulvar LS (18). With high rates of recurrence and often disfiguring results, this approach is now rarely indicated and should be reserved for malignancy and complications of scarring (2). Surgical approaches alone may exacerbate scarring through the Köebner phenomenon, in which normal skin becomes sclerotic due to trauma, leading to additional scarring. Application of ultrapotent TCSs following surgical intervention can lessen this effect. There may be a role for surgery combined with medical therapy in cases of urinary complications or sexual dysfunction due to LS-related adhesions and scarring. Even in these cases, surgical intervention is only recommended when conservative treatments fail (18).
Pharmacological Treatments for Localized Provoked Vulvodynia: A Scoping Review
Published in International Journal of Sexual Health, 2023
Krisztina Bajzak, Alex Rains, Lisa Bishop, Michelle Swab, Michelle E. Miller, Gabrielle S. Logan, Victoria Jackman, Liam Jackman, Diana L. Gustafson
The Vulvodynia Guideline originally published in 2006 (Schünemann et al., 2006) and updated in 2013 (Stockdale & Lawson, 2014) is a literature review and expert consensus document in the management of LPV. An evidence-based guideline with GRADE level recommendations for pharmacological management of LPV does not exist. In the absence of a society-endorsed guideline, the 2013 update is commonly used by clinicians to guide diagnosis and management. At the time, vulvectomy was included in the treatment algorithm supported by a robust body of evidence but was reserved for cases of vulvodynia that were refractory to other forms of medical treatments (Andrews, 2011; Stockdale & Lawson, 2014). A subsequent study found that management patterns varied widely across North America (Lua et al., 2017).
Laparoscopic inguinal lymph node dissection in carcinoma of the vulva: experience and intermediate results at one institution
Published in Southern African Journal of Gynaecological Oncology, 2021
Setheme Daniel Mosehle, Franco Guidozzi
Our results showed a mean operating time of 223 minutes (range 180–300) for the L-MILND and simple vulvectomy. In comparative studies, a significantly longer operative time was recorded with minimally invasive approach as compared with open techniques. Zhang and colleagues in their study comparing 48 patients who underwent L-MILND (21 patients) and standard inguinal lymphadenectomy (27 patients) in patients with vulval carcinoma, reported mean operative times were 109 ± 29.5 minutes and 45.3 ± 5.1 minutes, respectively (p < 0.001).16 Tobias-Machado et al. performed standard inguinal lymphadenectomy in 1 limb and L-MILND in the contralateral limb in 10 patients with penile cancer. They found operative time to be significantly longer in the L-MILND compared with the standard open procedure (126 vs. 92 minutes).12 Additionally, Abbot et al. in melanoma patients found operative time in L-MILND to be longer than in an open procedure (245 vs. 138 minutes).17 A systematic review by Liu and colleagues reported a total of 9 studies containing 249 L-MILND procedures in 138 patients; the operative time among these studies ranged between 62 and 110 minutes.18
Antiviral activity of curcumin-nanoemulsion associated with photodynamic therapy in vulvar cell lines transducing different variants of HPV-16
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Caroline Measso do Bonfim, Letícia Figueiredo Monteleoni, Marília de Freitas Calmon, Natália Maria Cândido, Paola Jocelan Scarin Provazzi, Vanesca de Souza Lino, Tatiana Rabachini, Laura Sichero, Luisa Lina Villa, Silvana Maria Quintana, Patrícia Pereira dos Santos Melli, Fernando Lucas Primo, Camila Fernanda Amantino, Antonio Claudio Tedesco, Enrique Boccardo, Paula Rahal
VIN treatment options include antiviral therapies such as cidofovir and intralesional or intramuscular interferon-α, as well as topical imiquimod application in the case of exophytic warts [7]. Additionally, vulvar lesions can also be removed surgically, by simple or radical vulvectomy. More advanced lesions can be treated with chemotherapy and radiotherapy and laser therapy may also be used in the treatment of VIN [8]. Unfortunately, adverse effects such as pain, irritation, superficial ulceration and hypersensitivity have been reported [9]. Since there is currently no effective therapeutic measure established, surgical removal, including both excision and ablation, is still recommended in more severe VIN cases. However, this intervention is still associated with high morbidity and high recurrence rates [8].