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Thermal Physiology and Thermoregulation
Published in James Stewart Campbell, M. Nathaniel Mead, Human Medical Thermography, 2023
James Stewart Campbell, M. Nathaniel Mead
Niacin is a B-vitamin that can be obtained from dietary sources. Dietary niacin supplying 50 to 100 mg per day does not appear to have significant thermographic effects. At pharmacologic doses of 1000 to 3000 mg, however, niacin has definite effects on skin blood flow (Figure 5.16). Flushing of the face is one of the most common side-effects associated with ingestion of niacin as well as nitrate medicines (nitroglycerine, isosorbide dinitrate, etc.) and PDE5 inhibitor drugs (sildenafil, etc.). Pharmacologic heat dissipation may be triggered by these vasodilating drugs. All forms of niacin should be avoided for about 8–12 hours before a thermographic exam.
Adnexal Diseases
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Hasan Aksoy, Jordan V. Wang, Ayşe Serap Karadağ
Clinical presentation: Rosacea has four clinical subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular (Table 3.4). Rosacea often presents earlier on as the erythematotelangiectatic subtype, which is characterized by persistent erythema, recurrent flushing, and telangiectasias on mid-face (Figure 3.4). Flushing can be triggered by physical, nutritional, or psychologic factors.
Paper 2
Published in Aalia Khan, Ramsey Jabbour, Almas Rehman, nMRCGP Applied Knowledge Test Study Guide, 2021
Aalia Khan, Ramsey Jabbour, Almas Rehman
Which of the following statements is false concerning acne rosacea? May present with recurrent facial flushing.Rhinophyma is a complication.Affects women more than men.Comedones are a feature.More common in fair-skinned people.
Are cyclosporine eye drops a suitable treatment in ocular rosacea?
Published in Journal of Dermatological Treatment, 2023
Alvaro Prados-Carmona, Juan J. Prados-Carmona, Marina Gálvez-Moreno, Ricardo Ruiz-Villaverde
The clinical picture of our patient included typical signs such as facial redness, papules, pustules and a history of repeated episodes of flushing. Besides that, since 6 months earlier, granulomatous lesions started to develop on her eyelids (Figure 1), leading to the avoidance of social events and impairing the patient’s quality of life. She had carried out 84 days of treatment with doxycycline 100 mg daily without clinical improvement. We prescribed isotretinoin 20 mg a day and a topical cleansing-moisturizing routine based on glycerin, niacinamide, and hyaluronic acid. After more than 2 months of treatment with no visible response, we added cyclosporine 0.05% eye drops once a day, leading to major improvement and resolution within 5 months with no adverse effects (Figure 2). The patient was followed up for 3 months without relapses and was eventually discharged.
College students’ use of strategies to hide facial flushing: A target for alcohol education
Published in Journal of American College Health, 2020
Karen G. Chartier, E. Clare Tiarsmith, Taryn O'Shea, Kenneth S. Kendler, Danielle M. Dick
The alcohol flushing response is an adverse reaction to the metabolism of ethanol,1 which occurs when deficient enzymes for metabolizing ethanol result in a buildup of acetaldehyde in the body.2 Alcohol-related flushing has a genetic basis. Two genetic markers associated with flushing are ADH1B*2 and ALDH2*2. They have different mechanisms affecting flushing; ADH1B*2 initiates a faster metabolism of ethanol to acetaldehyde whereas ALDH2*2 has a slower metabolism of acetaldehyde to acetate. The frequency of these genetic markers varies across populations groups. ADH1B*2 is found in 80% or more of northeast Asians (Chinese, Japanese, and Koreans) and about 10% of individuals of European ancestry.1 The ALDH2*2 variant is found almost exclusively in people of northeast Asian descent with the prevalence varying across specific Asian groups.1
To test or not to test: A study examining the return rates of rosacea patients treated with a pulsed dye laser
Published in Journal of Cosmetic and Laser Therapy, 2018
Molly Hirt, Ryan Mello, Scott Lunos, Ronda S Farah
Erythematotelangiectatic rosacea (ETR) is a subtype of rosacea that often manifests as prolonged flushing and telangiectasias along the central face, which can become persistent over time (1). Flushing is exacerbated by various stimuli such as spicy food, alcohol, hot drinks, emotional stress, hot showers, and exercise. Topical medications often used to treat rosacea include metronidazole, sodium sulfacetamide with sulfur, and azelaic acid gel (2). However, many patients with ETR have irritation resulting in pain, burning, and stinging pain with use of topical medications (1). Therefore, additional treatment options such as pulsed dye lasers (PDLs) have been shown to be an effective treatment for patients with ETR (3). The use of a PDL test area allows patients to experience PDL treatment on a small area prior to further treatment. In our study, we sought to formally investigate whether or not the use of a test area with no associated cost influenced return rate for further PDL treatment. We hypothesized that the use of a test area would increase the return rate for patients with rosacea for further PDL therapy.