China
Africa
Explore chapters and articles related to this topic
Selected topics
Published in Henry J. Woodford, Essential Geriatrics, 2022
Pseudogout produces hot, red, swollen joints that can be hard to distinguish clinically from gout or septic arthritis.30 The knee is the most commonly affected joint, followed by the wrist. There may be associated pyrexia. Attacks can last for several weeks. It may occur secondary to a number of disorders. These include hyperparathyroidism, haemochromatosis and hypomagnesaemia. X-rays may reveal chondrocalcinosis (a line of calcium along the articular cartilage) or hook-like osteophytes. Chronic CPP disease can resemble OA clinically.
The Musculoskeletal System and Its Disorders
Published in Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss, Understanding Medical Terms, 2020
Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss
The term gout refers to a group of disorders displaying elevated uric acid blood levels (hyperuricemia), crystalline deposits in tissues (tophi), and recurrent episodes of acute (gouty ) arthritis. Chandrocalcinosts results from deposits of calcium pyrophosphate dihydrate (CPPD) crystals in cartilage. Pseudogout is an acute inflammatory arthritis also involving CPPD crystals.
Answers
Published in Andrew Schofield, Paul Schofield, The Complete SAQ Study Guide, 2019
Andrew Schofield, Paul Schofield
Pseudogout is caused by the deposition of calcium pyrophosphate in cartilage. It presents in a similar way to gout, although affects different joints, commonly the knee or wrist, and is commoner in elderly women. Radiographs may reveal calcium deposition, but the diagnosis is ultimately made by identifying weakly positive biréfringent crystals in synovial fluid. Pseudogout often resolves spontaneously, but if it fails to settle, NSAIDs and other simple analgesics are used. Younger people presenting with this condition often have risk factors for the condition, such as Wilson’s disease or hyperparathyroidism.
Findings in ancient Egyptian mummies from tomb KV64, Valley of the Kings, Luxor, with evidence of a rheumatic disease
Published in Scandinavian Journal of Rheumatology, 2023
LM Öhrström, R Seiler, S Bickel, F Rühli
Psoriasis is probably known since antiquity (26). Evidence for SLE is also documented in ancient times, with the first case found in an Andean mummy (ca. AD 890) (27). So far, there is no consensus on the first occurrence of RA. While some authors state that RA was present in ancient Egypt (28, 29), others deny these assertions (30). Finally, there is no convincing evidence that RA was present in ancient Egypt (31). One of the oldest cases of spondyloarthritis in western Europe was identified in a skeleton from a Neolithic grave dating to the 4th millennium BCE (32). However, reports of the occurrence of ankylosing spondylitis in ancient Egyptian mummies are increasingly being revised (33, 34). There is some convincing evidence of the presence of JIA in ancient human skeletons (35, 36). While gout has been known since antiquity, pseudogout is a more recent disease (37).
Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study
Published in Current Medical Research and Opinion, 2021
Ki-Mo Jang, Yong-Geun Park, Won Kee Choi, Young Yool Chung, Kwang Kyoun Kim, Jang Woo Lee, Soong Joon Lee, Yunae Eom, Jae-Hyuk Yang
Among the acute local adverse reactions following intra-articular HA injections, pseudoseptic reactions have been reported as a kind of serious adverse reaction requiring further medical treatment50,64,65. Pseudoseptic reactions have certain features, which include severe inflammation of the joint, often with significant polymorphonuclear cellular effusion and significant pain; occurrence after more than one injection; ruling out of gout, pseudogout, or septic arthritis through the absence of infectious agents and uric acid or calcium pyrophosphate crystals in the synovial fluid; and high counts of mononuclear cells in the synovial fluid. The mechanism of onset of acute pseudoseptic arthritis following HA injections has not yet been elucidated. A few hypotheses have proposed an immunological basis to explain the physiopathology of pseudoseptic arthritis. One of the hypotheses was that proinflammatory cytokines play an important role in immunological reactions66. Although there are several reports regarding acute pseudoseptic reactions related to commonly used HA agents in clinical practice48,50,67,68, such serious local adverse events did not occur in this study.
Infective endocarditis initially manifesting as pseudogout
Published in Baylor University Medical Center Proceedings, 2021
Tim Brotherton, Chad S. Miller
Typical features of IE include fever, general malaise, weakness, immunologic phenomena (e.g., Osler’s nodes, Roth spots), and vascular phenomena (e.g., septic emboli, Janeway lesions). Musculoskeletal manifestations are relatively common, occurring in 19% to 44% of patients.3 Myalgias with arthralgia/arthritis are the most common musculoskeletal complaint and may be the only musculoskeletal manifestation.4,5 These initial musculoskeletal manifestations distract from the underlying diagnosis, which may delay time to appropriate treatment and increase mortality. A literature review using PubMed, Cochrane, and MEDLINE between 2000 and 2020 uncovered a case of IE manifesting with septic arthritis and pseudogout but no other cases that manifested with pseudogout in the absence of a septic joint.