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Inflammatory, Hypersensitivity and Immune Lung Diseases, including Parasitic Diseases.
Published in Fred W Wright, Radiology of the Chest and Related Conditions, 2022
Radiological examination was often under their control of the chest physicians, who performed both plain radiography and fluoroscopy for the diagnosis and control of treatment. The Mass Miniature Radiography Service was set up during World War II (largely using photofluorography) and continued until the 1970s when the very small number of positive cases, plus the relatively high radiation dose, made it no longer worthwhile (see also p. 20.3 and Appendices p. 1).
Development of plasma ghrelin level as a novel marker for gastric mucosal atrophy after Helicobacter pylori eradication
Published in Annals of Medicine, 2022
Hideki Mori, Hidekazu Suzuki, Juntaro Matsuzaki, Kaori Kameyama, Koji Igarashi, Tatsuhiro Masaoka, Takanori Kanai
Helicobacter pylori causes gastric cancer by directly injecting the oncoprotein CagA into gastric epithelial cells and inducing carcinogenesis; therefore, eradicating H. pylori prevents carcinogenesis. However, there is a risk of developing gastric cancer even after curing H. pylori infection and after treatment of gastric inflammation [1–4]. A longitudinal cohort study showed that the more extensive atrophic gastritis at the time of H. pylori eradication, the greater the incidence of gastric cancer after eradication [5]. The only current tool for assessing the extent of gastric mucosal atrophy is direct endoscopic evaluation; however, endoscopy is an invasive procedure that can cause severe discomfort for some patients. Population-based gastric cancer screening has been conducted under a governmental subsidy in Japan, but Japanese gastric cancer screening with X-ray photofluorography or endoscopy has been criticized for its low uptake rate [6]. Therefore, there is a need to develop a non-invasive modality that can assess the degree of gastric mucosal atrophy, regardless of the presence or absence of H. pylori infection.
SERPINE1 as a cancer-promoting gene in gastric adenocarcinoma: facilitates tumour cell proliferation, migration, and invasion by regulating EMT
Published in Journal of Chemotherapy, 2019
Jun-Dong Yang, Lin Ma, Zhen Zhu
Gastric cancer (GC), with gastric adenocarcinoma (GAC) as the most common histological type,1 is the third common cause of cancer death.2 With regard to cancer incidence worldwide, GC is more representative in Asia than other continents.3 Approximately 410,400 new cases of GC and 293,800 cancer-related deaths occurred in China in 2014, so there is still a heavy burden of GC in our country.4 With the development of the diagnostic radiology, most early gastric cancer (EGC) can be diagnosed by esophagogastroduodenoscopy and barium X-ray with photofluorography, and the 5-year survival rate of EGC can be achieved >95% by surgery treatment.5,6 Unfortunately, most patients (>70%) are diagnosed during middle or advanced stage, so the best time of surgery is missed. At present, targeted therapy is increasingly used to control tumour growth and prolong the life cycle, and many genetic alterations have been identified as potential targets for GC treatment.7,8 Based on this, our study aimed to identify effective therapeutic targets, hoping to provide a potential useful biomarker for GAC treatment.