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Defining Mystical States and Experiences
Published in Andrew C. Papanicolaou, A Scientific Assessment of the Validity of Mystical Experiences, 2021
Now, there is no scale to assess directly and quantitatively what I just called “intensity” because with the word intensity I am here alluding to a magnitude that is less quantitative and more quality-like. There are, however, approximations to accurate quantitative scales that are used for assessing drug-facilitated experiences in laboratory experiments9. These consist of estimates, on the part of the experimental subjects, of the “strength” or the “depth” or the «intensity» or the degree of persuasiveness of the experience relative to other, ordinary, but extremely important ones in their life. Most drug-facilitated mystical states are not authentic or fully developed ones (see chapter 3, in particular) and only a small percentage of participants in such studies report that they reach the highest level of “intensity” the scales allow.
Introduction and orientation to this guide
Published in Robert McAlpine, Anthony Hillin, Interpersonal Psychotherapy for Adolescents, 2020
Robert McAlpine, Anthony Hillin
The spectrum of intervention (from low to high intensity) matched to client need may include prevention programs, watchful waiting, psychoeducation, social support, non-directive supportive therapy, guided self-help, group programs, psychotherapy, medication, electroconvulsive therapy (ECT), and inpatient care. Low intensity options may include online interventions. Attention to suicide risk is required in all presentations of depression.
Doctor-Patient Communication and Adherence to Treatment
Published in Lynn B. Myers, Kenny Midence, Adherence to Treatment in Medical Conditions, 2020
The final problem with the traditional conceptualisation of adherence is the assumption that the patient will unquestioningly follow any advice that is given. The evidence is that patients come to the doctor with a more complex agenda and are more active in their own health care than this conceptualisation suggests. Regimes tend to be modified or distorted rather than completely accepted or abandoned. In describing this, Kjellem et al. (1995) suggested that adherence should be viewed as a matter of “more or less” rather than “yes or no”. Whilst some of the modifications that patients make to their regimes are unintentional as a result of not being able to understand or recall the advice (Ley, 1977), patients also actively alter the recommended course of treatment, depending on their beliefs about the adequacy of the proposed regime (Stimson, 1974; Hayes-Bautista, 1976; Zola, 1980; Hessen-Klemen and Lapinska, 1984). This can result in a number of outcomes: partial adherence to the recommendations, partial adherence supplemented by other patient-generated remedies, and even over-adherence, in which the patient increases the frequency or intensity of the prescribed treatment.
Severe immunochemotherapy-induced toxicities in a patient with dyskeratosis congenita and literature review
Published in Hematology, 2022
Jiayi Geng, Menglin Zhao, Qiuyu Li
Early recognition of DC is very important; thus, physicians should be more careful when potentially toxic therapies are administered. However, it may be challenging because family and personal history are often inconspicuous[12], and physicians may lack the essential knowledge to identify this rare disease. In China, most DC cases are diagnosed in dermatological departments[16]; thus, we suggest that physicians in other departments request a dermatology consultation after finding skin or mucosal abnormalities in patients with unknown cytopenia. In addition to an increased risk of cancer, patients with DC are predisposed to unreversible manifestations, such as bone marrow failure, pulmonary fibrosis, liver disease and vascular abnormalities. External pressure factors such as chemotherapy or radiation therapy can trigger or accelerate these lethal manifestations. Therefore, a reduced intensity of chemotherapy, immunochemotherapy or radiation therapy was recommended[17].
Epigenetic regulation of radioresistance: insights from preclinical and clinical studies
Published in Expert Opinion on Investigational Drugs, 2022
Katherine Shishido, Alexis Reinders, Swapna Asuthkar
Since its discovery in the late 19th century, RT has become widely used to treat various cancers and is largely responsible for improving survival rates, along with new chemotherapies and advanced surgical interventions. However, complications from RT, including sub-optimal targeting of tumors, have become a major drawback impacting treatment efficacy, remission rates, and progression-free survival. Radiotherapies must strike a delicate balance between ensuring patient safety and providing efficacious treatment to prevent disease recurrence. Oftentimes, the intensity of therapy is compromised in order to ensure patient safety. This is particularly true for patients with brain tumors, in part due to the presence of brain tumor-initiating cells that possess stem cell properties and are able to self-renew and differentiate [153]. Ideally, the elimination of the cancer stem cell (CSC) population within a tumor can be achieved through high-dose radiation. However, such exposure is limited in clinical practice to protect adjacent healthy tissue. Moreover, CSCs are inherently radioresistant and promote brain tumor recurrence after radiotherapy [154].
Body image, physical activity, quality of life, and community reintegration of individuals with acquired mobility disability in a Nigerian population
Published in Disability and Rehabilitation, 2022
Emmanuel Chiebuka Okoye, Ifeoma Uchenna Onwuakagba, Kenneth Umezulike Ani, Jacob Kolawole Babatunde, Christopher Olusanjo Akosile, Monique Chinyere Okeke, Ann Ebele Aronu
The IPAQ-SF is a seven-item questionnaire that records the activity of four intensity levels: vigorous, moderate, walking, and sitting. It assesses the frequency and duration of these intensity levels. Physical activity is then recorded in average minutes of participation per day and the number of days during the past 7 days in which the subject engaged in vigorous, moderate, or walking activities. The IPAQ-SF is scored by rating physical activity level as multiples of metabolic equivalents (METS) expressed as MET-min per week: vigorous (8 METS), moderate (4METS), and walking (3.3 METS). The WHO recommended a weekly physical activity level of at least 1200 MET-min/week [54]. The IPAQ-SF was reported to have acceptable measurement properties for monitoring population level of physical activity among 18 to 65 years adults in diverse settings. Its test-retest reliability (ICC = 0.33–0.73), criterion validity (r = 0.8 and r = 0.3), and concurrent validity (p = 0.78–0.92) had been reported [54]. The IPAQ-SF has been cross-cultural adapted and validated into the Nigerian (Igbo) environment (published data).