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Emerging Biomedical Imaging
Published in Lawrence S. Chan, William C. Tang, Engineering-Medicine, 2019
Having described the history of photoacoustic imaging, we will now discuss the principles of photoacoustic imaging. First, a general framework of how photoacoustic imaging is generated will be discussed, followed by two key steps of the imaging processes: (1). The Signal generation and (2). The image formation.
Introduction to optical imaging
Published in Ahmad Fadzil Mohamad Hani, Dileep Kumar, Optical Imaging for Biomedical and Clinical Applications, 2017
Dileep Kumar, Ahmad Fadzil Mohamad Hani
Photoacoustic imaging works on the principle of conversion of absorbed optical energy into acoustic energy, as acoustic waves scatter less than the optical waves in tissue, resulting in sharp and precise molecular imaging. Photoacoustic imaging generates images with higher resolution in diffusive regimes and optical ballistic [28].
A versatile nanoplatform for synergistic chemo-photothermal therapy and multimodal imaging against breast cancer
Published in Expert Opinion on Drug Delivery, 2020
Tingting Li, Yue Geng, Hanxi Zhang, Jing Wang, Yi Feng, Zhongyuan Chen, Xiaoxue Xie, Xiang Qin, Shun Li, Chunhui Wu, Yiyao Liu, Hong Yang
Two hundred fifty microliter aliquots of M-MSN-HA/DI aqueous solution at the concentrations of 2, 4, 8, 12, 16, and 20 μg/ml were prepared. A solution of an equivalent volume of 1% agarose was added to the above solutions of M-MSN-HA/DI. When the agarose hardened sufficiently, MR imaging and T2 relaxation were performed at 25°C by a 3 T MRI scanner (MR750; GE Discovery, Milwaukee, WI) in the MRI research center, University of Electronic Science and Technology of China. For in vitro photoacoustic imaging, a volume of ICG aqueous solution or M-MSN-HA/DI solution (at the ICG concentrations of 1, 2, 4, 8, and 16 μg/ml) was added into a tube with a length of 2 cm and a diameter of 0.3 cm, and the tube was fixed in a custom-built agarose mold. Photoacoustic imaging was performed using a photoacoustic imaging system (VisualSonics, Inc., Toronto, Canada).
A promising cancer diagnosis and treatment strategy: targeted cancer therapy and imaging based on antibody fragment
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Xuhong Zhao, Qian Ning, Zhongcheng Mo, Shengsong Tang
In addition, antibody fragments can be applied to photoacoustic imaging with high sensitivity and high resolution. Photoacoustic imaging has a certain improvement in imaging depth compared to conventional optical imaging. In photoacoustic imaging, transient thermoelastic tissue expansion occurs at the imaged portion after pulsed laser irradiation, thereby producing sound waves that can be converted into images by the ultrasonic transducer. In one study, photoacoustic tracers formed by antibody fragment-coupled nanoparticles have better affinity for HER2-posvitive tumour, demonstrating the potential of antibody fragments for photoacoustic imaging [70].
Advances in imaging techniques to assess kidney fibrosis
Published in Renal Failure, 2023
Buchun Jiang, Fei Liu, Haidong Fu, Jianhua Mao
Photoacoustic imaging (PAI) is a new noninvasive technique that combines ultrasound and laser without radiation. PAI can use ultrasound to detect the acoustic signals produced by the thermoelastic expansion of tissues, which is caused by laser irradiation. Because of the different light-absorption spectra of tissue components, PAI can quantify the collagen content in the kidneys and reflect the progression of fibrosis.