China
Africa
Explore chapters and articles related to this topic
Thyroid Malignancy and Dyshormonogenetic Goiter
Published in Geraldo Medeiros-Neto, John Bruton Stanbury, Inherited Disorders of the Thyroid System, 2019
Geraldo Medeiros-Neto, John Bruton Stanbury
Based on these rigid criteria, 8 of the 15 cases13,18-20,23,28 in the literature purported to be clear examples of thyroid malignancy in association with familial goiter. Four other reports14,24,26,27 could be accepted as true thyroid carcinoma but lack of photographic evidence of vascular invasion made the author’s diagnosis questionable. We also critically reviewed the reported cases of thyroid carcinoma arising in patients with congenital goiter. The patient with defective dehalogenase defect with a large goiter (100 g) described by McGirr et al.18 had infiltration of the capsule of the gland and epithelial cells were in close contact with striated muscle. Papillary formation was a prominent feature. There was invasion of small lymphatic channels in the adventitia of large arteries with fragmentation and interruption of the elastic lamina. Many large blood vessels contained epithelial cells. The diagnosis was papillary adenocarcinoma documented with several photomicrographs.
Nitrosamine-Induced Nasal Cavity Carcinogenesis
Published in D. V. M. Gerd Reznik, Sherman F. Stinson, Nasal Tumors in Animals and Man, 2017
In dogs, DEN and nitrosopiperidine have been reported to induce nasal cavity tumors.84,85 Both nitrosamines induced mainly tumors of squamous differentiation (squamous cell carcinomas, mucoepidermoid carcinomas), some of which metastasized to the lungs. In addition, one papillary adenocarcinoma was described.
Gallbladder Cancer
Published in Dongyou Liu, Tumors and Cancers, 2017
Adenocarcinoma arises in the gland cells lining the gallbladder, with papillary adenocarcinoma developing in the connective tissues that hold the gallbladder in place, and mucinous adenocarcinoma found in pools of mucus. SCC evolves from the skin-like cells along with the gland cells lining the gallbladder. Adenosquamous carcinoma has both squamous cell and glandular cell components. Small cell (oat cell) carcinoma contains abnormal cells of a distinctive oat shape. Sarcoma begins in the muscle layer of the gallbladder [2].
Characteristic analysis of early gastric cancer after Helicobacter pylori eradication: a multicenter retrospective propensity score-matched study
Published in Annals of Medicine, 2023
Xinyuan Liu, Xinyu Wang, Tao Mao, Xiaoyan Yin, Zhi Wei, Jindong Fu, Jie Wu, Xiaoyu Li
Figure 2 presents the endoscopic and histopathological images of a well-differentiated adenocarcinoma in a middle-aged male patient after H. pylori eradication. A 25 × 25-mm reddish depressed lesion was observed on the anterior wall of the upper part of the gastric antrum (Figure 2(A)). The surrounding mucosa showed map-like redness. The boundary of the lesion was clear on NBI magnifying endoscopy, with grid-like microvessels and disordered surface microstructures (Figure 2(B)). The gastric mucosa around the tumor was atrophied under low magnification, showing gastric pits, decreased glandular layers, and moderate intestinal metaplasia. Some glands were more proliferative, and lymphocytes and plasma cells infiltrated the interstitium (Figure 2(C)). When properly magnifying the adenocarcinoma area, the gastric mucosa was destroyed and the glands mainly showed a thick true papillary structure. The vascular axis of the papilla was visible, and the surface was covered with atypical epithelium, showing a well-differentiated papillary adenocarcinoma. Tumors in a small part of the area expanded in the form of tube glands, with dilated and irregular lumens, and enlarged glands were observed in the deep part of the tumor (Figure 2(D)).
An unexpected tumour of the finger: review and management
Published in Case Reports in Plastic Surgery and Hand Surgery, 2019
N. Jumper, E. Caffrey, N. McInerney
One month following referral, the patient underwent excision biopsy of the lesion which was not found to be communicating with bone, nerve or tendon and the intra-operative impression was that of a ganglion cyst (Figure 2). The initial histopathology examination reported a circumscribed multinodular predominantly solid tumour (Figure 3(a,b)) ulcerating the overlying epidermis. There were focal papillary projections with tubular/ductal structures (Figure 3(c)) where ducts were lined by a double layer of epithelium consisting of inner cuboidal cells and an outer myoepithelial layer (Figure 3(d,e,f,g)). There was also evidence of lymphovascular invasion (Figure 3(h,i)), focally high mitotic activity (Figure 3(j)) and the tumour was shown to abut the margins. Immunohistochemistry was performed (Table 1) confirming a myoepithelial cell population expressing smooth muscle actin, calponin, D2-40 (Figure 3(i)) and p63 (Figure 3(f)). The tumour was classified as digital papillary adenocarcinoma. The histopathology sections were sent to an external institution for expert opinion and the diagnosis affirmed with recommendation of complete excision and close follow-up. This recommendation was echoed when the case was discussed at the local multi-disciplinary meeting.
Incidence, diagnostic, treatment and outcome of patients diagnosed with cancer of the pancreas during 1986–2009: a population-based study
Published in Scandinavian Journal of Gastroenterology, 2018
Sara B. Jonsdottir, Gunnar Juliusson, Jon Ö. Kristinsson, Johann P. Hreinsson, Jon G. Jonasson, Einar S. Björnsson
In P1, four (1.4%) patients were alive 5 years after diagnosis, two had adenocarcinoma, one mucinous cystadenocarcinoma and one had papillary adenocarcinoma. Three (0.9%) patients in P2 were alive 5 years after diagnosis, two had adenocarcinoma and one had papillary adenocarcinoma. Four had T2 tumors, two T3 and one had T4. All of these patients had a resection except for one patient with adenocarcinoma and T4 tumor. That patient had a double bypass and lived for 7 years after the surgery and then subsequently died from the disease. One patient with biopsy-proven adenocarcinoma in a regional lymph node (even after pathological re-examination) had a resection and is still alive 14 years after the operation.