Extrapulmonary restriction

Key cases – Treatable traits

Published in Vibeke Backer, Peter G. Gibson, Ian D. Pavord, The Asthmas, 2023

Vibeke Backer, Peter G. Gibson, Ian D. Pavord

Comment 2: No evidence of type-2 airway inflammation, airflow limitation or airway hyperresponsiveness and asthma can be excluded. Borderline restrictive spirometry and increased corrected gas transfer are in keeping with extrapulmonary restriction, likely secondary to obesity. This is the most likely cause for her exertional breathlessness. There is a clear potential for an erroneous diagnosis of asthma based on the possible response to salbutamol and for the patient to receive escalating anti-asthma therapy, with potential attendant adverse effects. The systematic treatable traits-based approach prevented this.

Rheumatoid arthritis related interstitial lung disease

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Journal Information

Published in Expert Review of Clinical Immunology, 2021

Andreina Manfredi, Giulia Cassone, Fabrizio Luppi, Belen Atienza-Mateo, Alberto Cavazza, Nicola Sverzellati, Miguel A. González-Gay, Carlo Salvarani, Marco Sebastiani

FVC is highly reproducible and its changes are specific to ILD, once extrapulmonary restriction due to pleural or muscle diseases has been excluded [67]. A disease progression may be expected in RA patients with a decline of at least 10% in FVC or of at least 15% in DLCO over 6–12 months [68].

Extrapulmonary restriction

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Key cases – Treatable traits

Rheumatoid arthritis related interstitial lung disease