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Antiasthma Agents during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Chapter 11 covers antihistamine and expectorant use during pregnancy. The following relevant medications are included in Chapter 11: brompheniramine, cetirizine, chlorpheniramine, dexchlorpheniramine, diphenhydramine, hydroxyzine, loratadine, oxymetazoline, pheniramine, phenylephrine, pseudoephedrine, tripelennamine and triprolidine are generally considered safe for use during pregnancy. Some literature suggests that expectorants and mucolytics have efficacy for asthma treatment.
Ethnomedicinal and Pharmacological Importance of Glycyrrhiza glabra L
Published in Mahendra Rai, Shandesh Bhattarai, Chistiane M. Feitosa, Wild Plants, 2020
Ashish K. Bhattarai, Sanjaya M. Dixit
Glycyrrhiza roots are useful for treating cough because of their demulcent and expectorant properties. The licorice powder and extract were found to be effective in treatment of sore throat, cough, and bronchial catarrh. It decreases irritation and produces expectorant effects. Licorice extract may stimulate tracheal mucous secretions producing demulcent and expectorant effects, although exact mechanism is not known. It efficiency is compared to be equivalent to that of codeine in sore throat (Murray 1998).
Mycoplasma Pneumoniae Pneumonia *
Published in Lourdes R. Laraya-Cuasay, Walter T. Hughes, Interstitial Lung Diseases in Children, 2019
Dry cough may persist for many days after antibiotic therapy is started and may require antitussive preparations containing codeine. As the cough is usually nonproductive, expectorants should be avoided to avoid bronchial irritation.
The beneficial effects of an adenotonsillectomy upon upper respiratory tract infections, asthma and rhinitis in children: a national database study in Korea
Published in Acta Oto-Laryngologica, 2023
Mi Rye Bae, Kyung-Do Han, Sang-Hyun Park, Yoo-Sam Chung
The prescription of expectorants, cough suppressants, oral bronchodilators, oral antihistamines, leukotriene modulators, oral steroids, and oral antibiotics was significantly reduced in our present surgery group compared with the control group. The number of prescription days for inhaled sprays and inhaled bronchodilators, which are mainly used for asthma, did not show a significant decrease after surgery. This observation is in line with the decrease in the number of outpatient visits and hospitalization days, which was more clearly evident among the patients with rhinitis and upper respiratory tract infection than in the asthma cases. Acknowledging that two or more drugs are often coadministered to control various symptoms of a disease, each drug does not represent a single specific disease. Furthermore, a particular drug can be used to control a variety of diseases. In particular, oral antibiotics are not used only for the respiratory diseases targeted in this study but are used to control a variety of infections. It is difficult therefore to interpret a decrease in the use of antibiotics after surgery directly as a decrease in the severity of a specific disease. However, considering that the burden of drug administration is greater in children than in adults, the significant decrease we here observed in the prescription of various drugs after surgery can be considered as a benefit of surgery.
Addressing unmet needs for diagnosis and management of chronic cough in the primary care setting
Published in Postgraduate Medicine, 2021
Peter Kardos, Michael Blaiss, Peter Dicpinigaitis
A 52-year-old female office worker who has never smoked sought consultation with her primary care physician with complaint of cough. The cough began ~7 years earlier upon the onset of a common cold; since then, the patient has had a persistent dry cough that occurs mostly during the day and worsens when lying down in the evening (but it does not disrupt her sleep at night). Infrequently, she expectorates minimal quantities of transparent phlegm, leading to some relief. Her medical history does not indicate any identifiable contributing factors to cough (e.g. environmental triggers, smoking) and she has no regular medication use. The patient has tried many over-the-counter expectorants and antitussives, but these medications only provide, at most, brief relief. Results from chest X-ray and spirometry were normal. Forced expiratory volume in 1 second (FEV1) was 85% of predicted volume. Pre- and postbronchodilator comparison was performed; an 8% improvement in FEV1 was observed, reflecting a negative bronchodilator response. How should this patient be diagnosed and treated?
Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice
Published in Pharmaceutical Biology, 2021
Jin-Ryul Hu, Chul-Jong Jung, Seong-Min Ku, Dae-Hwa Jung, Khawaja Muhammad Imran Bashir, Sae-Kwang Ku, Jae-Suk Choi
Linctus (a cough medication in syrup form) is used to treat cough and its related symptoms. For dry cough, treatments with antitussives or cough suppressants are used to suppress the body's urge to cough. Whereas, in productive coughs (producing phlegm), expectorants are used to loosen mucus from the respiratory tract (Smith et al. 2008; Dicpinigaitis 2012). Animal models including mice can be used to verify the antitussive effects of drugs by detecting and counting the number of coughs produced by tussive stimulus, like NH4OH given to animals, and by comparing the number of coughs induced in response to the administration of tussive, as an effective and simple experimental approach (Zhang et al. 2009; Wang et al. 2012). In this study, the antitussive effects of KOG were tested using the NH4OH exposure coughing mouse model. ASA is directly related to the gas exchange capacity of lung, the higher the ASA, the higher the gas exchange capacity (Davey et al. 2002; Choi et al. 2005; Ku et al. 2012).