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Children's Brain Trauma
Published in Rolland S. Parker, Concussive Brain Trauma, 2016
Dishabituation: This is the enhancement of a physiological response to a novel stressor in animals that had been exposed repeatedly or continuously to an unrelated stressor. If presented with an unfamiliar stressor, there is a much greater behavioral and physiological challenge than presentation of the same stressor to a naive (unstressed) control. The plasma catecholamine response is amplified compared to naive controls exposed to a similar stress.
Dietary n-3 polyunsaturated fatty acid deficiency alters olfactory mucosa sensitivity in young mice but has no impact on olfactory behavior
Published in Nutritional Neuroscience, 2023
Vanessa Soubeyre, Laetitia Merle, David Jarriault, Stéphane Grégoire, Lionel Bretillon, Niyazi Acar, Xavier Grosmaitre, Anne Marie Le Bon
Statistical tests were performed with Prism software (GraphPad, San Diego, USA). FA, anisotropy and gene expression data were analyzed using the nonparametric Mann–Whitney U test. A p value <0.05 was considered statistically significant. EOG recordings and sniffing behavior data were analyzed using two-way repeated-measures ANOVA followed by Bonferroni’s multiple comparison test. Data obtained in the habituation and dishabituation tests were analyzed using two-way repeated-measures ANOVA followed by Fischer’s LSD post hoc test.
A Bifactor Model of Personality Organization
Published in Journal of Personality Assessment, 2021
Susanne Hörz-Sagstetter, Jana Volkert, Michael Rentrop, Cord Benecke, Daniela J. Gremaud-Heitz, Human-Friedrich Unterrainer, Henning Schauenburg, Daniel Seidler, Anna Buchheim, Stephan Doering, Markus G. Feil, John F. Clarkin, Gerhard Dammann, Johannes Zimmermann
The study is based on 11 samples, described in Table 1. IPO data was available from a total of N = 616 individuals, and in some samples, additional measures of axis I and II pathology were assessed. Across all samples, participants had a mean age of 31.9 years (SD = 10.0) and 51.2% were female. The first sample (S1) is a healthy control sample of N = 50 from a larger study on the STIPO at the hospital of the Technical University Munich (Germany). The second sample (S2) consists of 52 patients with a BPD diagnosis in two inpatient units in Basel (Switzerland), who participated in a psychotherapy study (Sollberger et al., 2014). The third sample (S3) was part of a larger study on depression and consisted of 63 patients from the Heidelberg University Hospital (Germany) (Franz et al., 2015). The fourth sample (S4) consisted of 45 patients with polytoxicomania, who were in detoxification treatment at the hospital of the Technical University Munich (Rentrop, Zilker, Lederle, Birkhofer, & Hörz, 2014). The fifth sample (S5) comprised 12 patients from a psychotherapeutic outpatient clinic for violent and sexual offenders in Munich (Feil, 2016). Sample S6 consisted of a sub-sample of N = 30 of women with BPD from a larger RCT in Munich (study comparing outpatient transference-focused therapy with treatment as usual) (Doering et al., 2010). Sample S7 comprised a group of 36 patients in opiate dehabituation treatment at the “Würmtalklinik Gräfelfing” near Munich (Germany). S8 is a sample of 75 male criminal offenders from a study in a German forensic hospital (Dammann, Gremaud-Heitz, Scharnowski, & Ptucha, 2011). Sample S9 were 11 patients from an inpatient unit on personality disorders at the Psychiatric Hospital Münsterlingen (Switzerland). Sample S10 consisted of 104 psychiatric inpatients from the University Hospital in Graz (Austria), and Sample S11 consisted of 138 female patients from a larger naturalistic multicenter intervention study to document the effectiveness of psychodynamic inpatient treatment on depressive symptom load (Franz et al., 2015; Seidler, Schäfer, Jenett, Hartkamp, & Franz, 2017). All studies were approved by the local ethics committees.
But can they learn? My accidental discovery of learning and memory in C. elegans
Published in Journal of Neurogenetics, 2020
Looking back, my research trajectory into C. elegans happened entirely by chance as a result of the convergence of potential disasters and fortuitous moments. My undergraduate and graduate degrees were in Psychology. For my post-doctoral research, I studied the development of learning and memory in juvenile Aplysia californica with Dr. Thomas Carew in the Psychology Department at Yale University. We focused on the simplest forms of learning that primarily require only a single stimulus (single or repeated presentations): non-associative habituation, dishabituation and sensitization. Baby Aplysia are about 1 mm in diameter and had not previously been studied behaviorally and so I had to develop techniques to hold them still under the microscope, stimulate them and study their learning. When I began my first faculty position in the Psychology Department at the University of British Columbia in August of 1987, I started buying equipment to set up a lab to continue to study learning in juvenile Aplysia. Several things interrupted my forward progress – the mariculture facility that supplied the baby Aplysia was moving to a new location and closing for a year so no Aplysia would be available, and one of the vendors who was building some equipment for me demanded payment in advance and several months later ran away with a significant proportion of my already small start-up funds. Both events were potential disasters for a junior Assistant Professor, and it could have been tempting to give up! At the same time these disasters occurred I was trying to decide on the brand of dissecting microscope to purchase to equip my laboratory, and no one in the Psychology department then knew much about different brands of microscopes. I began asking everyone I met about microscopes and one day an undergraduate student I met told me he had worked in another lab with a number of different kinds of dissecting scopes and I should get in touch with the researcher in charge of that laboratory and get a recommendation. I did just that – I called Ann Rose in Medical Genetics at UBC and asked her about microscopes. She graciously extended an invitation for me come by her lab to look at the microscopes she used and I accepted her offer. When I visited her lab, she was very generous with her time and told me about the genetic research she was doing on the microscopic, 1 mm long nematode C. elegans. I was excited that her worms were the same size as my baby Aplysia and so I asked for some to use to test out all of the loaner microscopes that the salespeople had left for me. She agreed and sent me back to my office with a plate of worms.