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Emblicanin-A and Emblicanin-B: Pharmacological and Nano-Pharmacotherapeutic Perspective for Healthcare Applications
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Mohamad Taleuzzaman, Debarshi Kar Mahapatra, Dipak Kumar Gupta
The phenolic constituents of P. emblica are not as effective as single but its nanoemulsion formulation for the topical administration showed a good result. The microemulsion technique was used for the preparation of nanoemulsion with hot high-pressure homogenization. The nanoemulsion was optimized by the ternary phase diagram. The formulation is composed of isopropyl myristate (0.6% w/w) and median particle size of 191.63 ± 4.07 nm with a narrow particle size distribution, a ZP of −10.19 ± 0.54 mV. High entrapment efficiency at 67.99 ± 0.87% and good stability at 4°C after 90 days of storage have been seen. From the nanoemulsion, the release of active drug was higher as compared to the aqueous formulation.38
Nanocarrier Technologies for Enhancing the Solubility and Dissolution Rate of Api
Published in Debarshi Kar Mahapatra, Sanjay Kumar Bharti, Medicinal Chemistry with Pharmaceutical Product Development, 2019
Ashwini Deshpande, Tulshidas S. Patil
The solubility studies of the drug are carried out in different lipids, surfactants and co-surfactants by adding excess amount of drug. The Pseudo ternary phase diagram is constructed to identify the self-emulsifying region and to select the optimum percentage of oils, surfactants and co-surfactants in the formulation of SNEDDS [132]. For constructing pseudoternary phase diagram, water titration method is widely used [133–136]. The ternary phase diagram can be drawn by different softwares like Origin Pro 8.6 [133], PCP Disso software V3.0 [137, 138] CHEMIX® ternary plot software [139, 140], and Tri plot v1–4 software [141].
Skin pigmentation improvement with resveratrol microemulsion gel using polyoxyethylene hydrogenated castor oil
Published in Drug Development and Industrial Pharmacy, 2023
Lu Cao, Xiaoyan Li, Jing Zhao, Qing Du, Jiening Dun
The pseudo-ternary phase diagram was established at room temperature. Glycerol triacetate was used as the oil phase, polyoxyethylene 40 hydrogenated castor oil(RH-40) as an emulsifier, and polyethylene glycol 400(PEG-400) as a co-emulsifier. First, the emulsifier and co-emulsifier were mixed with a mass ratio (Km) of 1:1, 2:1, and 3:1, after which the oil phase was mixed with a mass ratio of 9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8 and 1:9. In the constant temperature magnetic agitator (Henan Great Wall Technology and Trade Co., LTD.), the distilled water was added to the mixture drop by drop until the formation of a transparent, transparent, uniform microemulsion. The amount of each component was recorded, and the pseudo-ternary phase diagram was drawn according to the mass percentage of oil, water, and mixed emulsifier at the critical point. Four points were randomly selected in the microemulsion region with Km value of 2:1, and four prescriptions were obtained to prepare blank microemulsion according to the ratio of four components. The microemulsion’s appearance, particle size, PDI, centrifugal stability, and maximum drug loading were used as evaluation indexes to screen the microemulsion prescription.
Improved anti-inflammatory effect of curcumin by designing self-emulsifying drug delivery system
Published in Drug Development and Industrial Pharmacy, 2021
Muhammad Hanif, Nabeela Ameer, Muhammad Khalid Mahmood, Ahmed Shehzad, Muhammad Azeem, Hafsa Latif Rana, Muhammad Usman
The objectives of present study were to design, prepare, and characterize Cur SEDDS, and assess its release and anti-inflammatory effect of Cur in albino rats. In this study, to develop an SEDDS containing poorly water-soluble Cur, various oils, surfactants, and cosurfactants were selected to optimize the formulation. The solubility of Cur in various oils and cosurfactants was investigated to find suitable ingredients with a good solubilizing capacity. Pseudo-ternary phase diagram was also constructed. Furthermore, its quality in vitro and its bioavailability in mice in vivo were assessed. The promising results such as increased solubility, enhanced oral bioavailability, anti-inflammatory activity obtained through formulation development of Cur SEDDS are discussed here.
A comprehensive study of the basic formulation of supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) of albendazolum
Published in Drug Delivery, 2021
Hani Alothaid, Mohammed S. Aldughaim, Azeez Oriyomi Yusuf, Umama Yezdani, Alaa Alhazmi, Mahmoud M. Habibullah, Mohammad Gayoor Khan
Ternary phase diagrams using the selected oil (oleic acid), surfactant (tween 20), and co-surfactants (PEG 600) were constructed to identify the specific locations at which self-emulsification occurred by dilution using previously published method (Elkasabgy, 2014). Ternary phase diagrams show the optimum ingredients and ratios of these ingredients in mixtures used for the preparation of a stable SNEDDS. Ternary mixtures were prepared using different combinations of the concentrations of the components, after which a ternary phase diagram was constructed for each mixture. Self-emulsifying ability of each point on the phase diagram was tested by diluting one gram of the corresponding ternary mixture up to 10 mL with distilled water in a capped vial, which was then magnetically stirred at a rotation speed of 125 rpm at 37 °C for 3 min. Phase separation of the diluted mixtures was then evaluated visually. Dispersions with a clear or slight bluish appearance were considered to be in the nanoemulsion region of the diagram.