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Genomics and Hearing Loss: Toward a New Standard of Care?
Published in Stavros Hatzopoulos, Andrea Ciorba, Mark Krumm, Advances in Audiology and Hearing Science, 2020
The TECTA gene (DFNB21) encodes α-tectorin, an extracellular protein constituent of the tectorial membrane and the otolithic membrane in the cochlea and vestibular systems, respectively. Families with autosomal dominant nonsyndromic hearing loss and autosomal recessive nonsyndromic hearing loss have been reported to carry mutations in TECTA.
Comparative Anatomy and Histomorphology of the Nasal and Paranasal Cavities in Rodents
Published in D. V. M. Gerd Reznik, Sherman F. Stinson, Nasal Tumors in Animals and Man, 2017
Kelemen and Sargent11 and Kelemen12 did not describe the nasoturbinal in rats; Och6 stated that the nasoturbinal extends up to the lamina cribrosa. The nasoturbinal of the EH corresponds to the pars libera described by Zuckerkandl8 and is situated directly behind atrioturbinal 2. It does not extend beyond the respiratory region. The pars tecta or the processus uncinatus is the same structure as ectoturbinal 1 of the ethmoturbinal of the EH. The latter forms the medial wall of the anterior-superior of the sinus maxillaris. The pars tecta of Zuckerkandl8 in the EH is also found behind the first olfactory concha of the medial row of the ethmoturbinals. This is endoturbinal 1 in the EH. Contradictions between the older and more recent literature may reflect different methods and may have also been caused by the fact that at that time only embryonal tissue could be cut and examined as graded sections.
Specific Synonyms
Published in Terence R. Anthoney, Neuroanatomy and the Neurologic Exam, 2017
Prehippocampal rudiment (W&W, p.997) Taenia tecta (N&F, p. 228)See, also, D: Hippocampal rudiment.
Molecular testing for the study of non-syndromic hearing loss
Published in Hearing, Balance and Communication, 2020
Anna Morgan, Paolo Gasparini, Giorgia Girotto
During the last decade, many laboratories all over the world employed TRS or WES for the molecular analysis of hereditary hearing loss, confirming the feasibility of this approach. Overall the results of NGS corroborate the heterogeneity of the disease and highlight many differences in the aetiology of HL between populations. As an example, a study on 1119 American patients revealed that in addition to GJB2, the other three genes most frequently mutated in NSHL patients were STRC, SLC26A4, and TECTA [37]. Another work on a series of 61 Egyptian consanguineous families indicates MYO15A, SLC26A4, GJB2 (at the third place) and MYO7A as the major players in this subset of patients [38]. The application of TRS in 116 Chinese individuals revealed that SLC26A4 and GJB2 were the most frequently affected genes among the Chinese Han population followed by MTRNR1, PCDH15, and TECTA [39]. In our cohort of patients GJB2, TECTA, ACTG1, TMPRSS3, STRC, MYO7A and MYO6 explained the majority of cases of a cohort of 103 patients [6], while in the Qatari population the main genes appeared to be CDH23 and TMC1 [40]. This variability among different ethnic groups suggests that specific strategies need to be tailored on populations cohort level.
Human cochlear microanatomy – an electron microscopy and super-resolution structured illumination study and review
Published in Hearing, Balance and Communication, 2020
Wei Liu, Rudolf Glueckert, Annelies Schrott-Fischer, Helge Rask-Andersen
A renewal was earlier proposed in adults [38]and during development [39]. According to Prieto et al., two secretion products could be involved in the turnover of the adult TM and/or secretion of some components. [40] In humans, α-tectorin seems to be translocated along the collagen fibres to reach the surfaces. It was more expressed in the high-frequency region and in the outer circumference of the TM. This may explain why some α-tectorin (TECTA) gene mutations cause more hearing loss at high frequencies [41]. Human α-tectorin underlies two dominantly inherited non-syndromic deafnesses, DFNA8 and DFNA12 [42,43]. Targeted gene disruption shows the intricate roles of α-tectorin and β-tectorin for OHCs to optimally stimulate the IHCs [44,45].
Why the olfactory acuity to Exaltolide test is different in women?
Published in Acta Oto-Laryngologica, 2021
Pedro Clarós, Regis Mbonimpaye, Andrés Clarós, Antonio Lopez
The sense of smell is a chemical sense dedicated to the perception of chemical stimulations and to the generation of responses to them. Smell perception depends on the odor receptor neurons, located in the olfactory epithelium, able to detect the identity and concentration of odors. Their axons form bundles projecting to the cribriform plate and synapse in the olfactory bulb. The main output from the olfactory bulb to olfactory cortex depends on MT cells and includes the anterior olfactory nucleus, tenia tecta, olfactory tubercle, cortical nucleus of the amygdala, anterior and posterior piriform cortex and the lateral entorhinal cortex [1]. Several studies reported that smell loss should negatively affect quality of life under its diverse aspects [2].